NSP2 (rotavirus)

From Wikipedia, the free encyclopedia

NSP2, is a Rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.[1] NSP2 is closely associated in vivo with the viral replicase.[2] The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2.[3]


  1. ^ Kattoura, M D; X Chen, J T Patton (1994- Aug- 1). "The rotavirus RNA-binding protein NSP2 forms 10S multimers and interacts with the viral RNA polymerase.". Virology 202 (2): 803–13. doi:10.1006/viro.1994.1402. 8030243 doi:10.1006/viro.1994.1402. 
  2. ^ Aponte, C; D Poncet, J Cohen (1996- Feb). "Recovery and characterization of a replicase complex in rotavirus-infected cells by using a monoclonal antibody against NSP2.". Journal of virology 70 (2): 985–91. 8551639. 
  3. ^ Fabbretti, E; I Afrikanova, F Vascotto, O R Burrone (1999- Feb). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo.". The Journal of general virology 80 ( Pt 2): 333–9. 10073692. 


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