NSFL1C

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NSFL1 (p97) cofactor (p47)
PDB rendering based on 1i42.
Available structures: 1i42, 1jru, 1s3s, 1ss6, 1v92, 1vaz
Identifiers
Symbol(s) NSFL1C; p47; MGC3347; UBXD10; dJ776F14.1
External IDs OMIM: 606610 MGI: 3042273 HomoloGene: 41114
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55968 386649
Ensembl ENSG00000088833 ENSMUSG00000027455
Uniprot Q9UNZ2 Q3KQQ1
Refseq NM_016143 (mRNA)
NP_057227 (protein)		 XM_972636 (mRNA)
XP_977730 (protein)
Location Chr 20: 1.37 - 1.4 Mb Chr 2: 151.19 - 151.2 Mb
Pubmed search [1] [2]

NSFL1 (p97) cofactor (p47), also known as NSFL1C, is a human gene.[1]

N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Multiple transcript variants encoding several different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: NSFL1C NSFL1 (p97) cofactor (p47).

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Kondo H, Rabouille C, Newman R, et al. (1997). "p47 is a cofactor for p97-mediated membrane fusion.". Nature 388 (6637): 75–8. doi:10.1038/40411. PMID 9214505. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Rabouille C, Kondo H, Newman R, et al. (1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro.". Cell 92 (5): 603–10. PMID 9506515. 
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946. 
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. PMID 11042152. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Meyer HH, Wang Y, Warren G (2002). "Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4.". EMBO J. 21 (21): 5645–52. PMID 12411482. 
  • Uchiyama K, Jokitalo E, Kano F, et al. (2003). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo.". J. Cell Biol. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMID 12473691. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nagahama M, Suzuki M, Hamada Y, et al. (2003). "SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation.". Mol. Biol. Cell 14 (1): 262–73. doi:10.1091/mbc.02-07-0115. PMID 12529442. 
  • Uchiyama K, Jokitalo E, Lindman M, et al. (2003). "The localization and phosphorylation of p47 are important for Golgi disassembly-assembly during the cell cycle.". J. Cell Biol. 161 (6): 1067–79. doi:10.1083/jcb.200303048. PMID 12810701. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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