NRXN3

From Wikipedia, the free encyclopedia

Neurexin 3

Identifiers

NRXN3; KIAA0743

External IDs

OMIM: 600567 MGI: 1096389 HomoloGene: 88711

Gene ontology
Molecular Function:	• receptor activity • calcium ion binding • protein binding
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• cell adhesion • axon guidance

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004796 (mRNA)
NP_004787 (protein)

NM_172544 (mRNA)
NP_766132 (protein)

Location

Chr 14: 77.78 - 79.4 Mb

Chr 12: 89.31 - 90.74 Mb

Pubmed search

[1]

[2]

Neurexin 3, also known as NRXN3, is a human gene.^[1]

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.^[1]

[edit] References

^ ^a ^b Entrez Gene: NRXN3 neurexin 3.

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Occhi G, Rampazzo A, Beffagna G, Antonio Danieli G (2002). "Identification and characterization of heart-specific splicing of human neurexin 3 mRNA (NRXN3).". Biochem. Biophys. Res. Commun. 298 (1): 151–5. PMID 12379233.
Tabuchi K, Südhof TC (2002). "Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.". Genomics 79 (6): 849–59. doi:10.1006/geno.2002.6780. PMID 12036300.
Rowen L, Young J, Birditt B, et al. (2002). "Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.". Genomics 79 (4): 587–97. doi:10.1006/geno.2002.6734. PMID 11944992.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452.
Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. PMID 9707552.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.
Hata Y, Butz S, Südhof TC (1996). "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.". J. Neurosci. 16 (8): 2488–94. PMID 8786425.
Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins.". J. Biol. Chem. 271 (5): 2676–82. PMID 8576240.
Ushkaryov YA, Petrenko AG, Geppert M, Südhof TC (1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.". Science 257 (5066): 50–6. PMID 1621094.