NRP2

From Wikipedia, the free encyclopedia

Neuropilin 2

Identifiers

NRP2; NP2; MGC126574; NPN2; PRO2714; VEGF165R2

External IDs

OMIM: 602070 MGI: 1100492 HomoloGene: 2875

Gene ontology
Molecular Function:	• receptor activity • vascular endothelial growth factor receptor activity • electron carrier activity • protein disulfide oxidoreductase activity • semaphorin receptor activity
Cellular Component:	• membrane fraction • membrane • integral to membrane
Biological Process:	• angiogenesis • neural crest cell migration • cell adhesion • multicellular organismal development • nervous system development • axon guidance • heart development • cell differentiation • cell redox homeostasis • negative chemotaxis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003872 (mRNA)
NP_003863 (protein)

NM_001077403 (mRNA)
NP_001070871 (protein)

Location

Chr 2: 206.25 - 206.37 Mb

Chr 1: 62.64 - 62.75 Mb

Pubmed search

[1]

[2]

Neuropilin 2, also known as NRP2, is a human gene.

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ Entrez Gene: NRP2 neuropilin 2.

[edit] Further reading

Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999). "Vascular endothelial growth factor (VEGF) and its receptors.". FASEB J. 13 (1): 9–22. PMID 9872925.
Kolodkin AL, Levengood DV, Rowe EG, et al. (1997). "Neuropilin is a semaphorin III receptor.". Cell 90 (4): 753–62. PMID 9288754.
Chen H, Chédotal A, He Z, et al. (1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III.". Neuron 19 (3): 547–59. PMID 9331348.
Giger RJ, Urquhart ER, Gillespie SK, et al. (1999). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.". Neuron 21 (5): 1079–92. PMID 9856463.
Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins.". Neuron 21 (6): 1283–90. PMID 9883722.
Takahashi T, Nakamura F, Jin Z, et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively.". Genomics 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. PMID 10520995.
Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected].". J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
Handa A, Tokunaga T, Tsuchida T, et al. (2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.". Int. J. Oncol. 17 (2): 291–5. PMID 10891538.
Rossignol M, Gagnon ML, Klagsbrun M (2001). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms.". Genomics 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.
Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes.". J. Biol. Chem. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.
Cohen T, Gluzman-Poltorak Z, Brodzky A, et al. (2001). "Neuroendocrine cells along the digestive tract express neuropilin-2.". Biochem. Biophys. Res. Commun. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.
Herzog Y, Kalcheim C, Kahane N, et al. (2002). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins.". Mech. Dev. 109 (1): 115–9. PMID 11677062.
Oh H, Takagi H, Otani A, et al. (2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 383–8. doi:10.1073/pnas.012074399. PMID 11756651.
Fakhari M, Pullirsch D, Abraham D, et al. (2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma.". Cancer 94 (1): 258–63. PMID 11815985.
Cohen T, Herzog Y, Brodzky A, et al. (2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours.". J. Pathol. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066.
Kawakami T, Tokunaga T, Hatanaka H, et al. (2003). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma.". Cancer 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.