NRIP1

From Wikipedia, the free encyclopedia


Nuclear receptor interacting protein 1
Identifiers
Symbol(s) NRIP1; RIP140
External IDs OMIM: 602490 MGI: 1315213 HomoloGene: 2606
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8204 268903
Ensembl ENSG00000180530 ENSMUSG00000048490
Uniprot P48552 Q3U166
Refseq NM_003489 (mRNA)
NP_003480 (protein)		 NM_173440 (mRNA)
NP_775616 (protein)
Location Chr 21: 15.26 - 15.26 Mb Chr 16: 76.17 - 76.26 Mb
Pubmed search [1] [2]

Nuclear receptor interacting protein 1, also known as NRIP1, is a human gene.

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: NRIP1 nuclear receptor interacting protein 1.

[edit] Further reading

  • Detlav IE (1976). "[Anti-brain antibodies in serum and cerebrospinal fluid following cranio-cerebral trauma]". Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) 76 (3): 344–8. PMID 1266503. 
  • Cavaillès V, Dauvois S, L'Horset F, et al. (1995). "Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.". EMBO J. 14 (15): 3741–51. PMID 7641693. 
  • L'Horset F, Dauvois S, Heery DM, et al. (1996). "RIP-140 interacts with multiple nuclear receptors by means of two distinct sites.". Mol. Cell. Biol. 16 (11): 6029–36. PMID 8887632. 
  • Katsanis N, Ives JH, Groet J, et al. (1998). "Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome.". Hum. Genet. 102 (2): 221–3. PMID 9521594. 
  • Yan ZH, Karam WG, Staudinger JL, et al. (1998). "Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4.". J. Biol. Chem. 273 (18): 10948–57. PMID 9556573. 
  • Treuter E, Albrektsen T, Johansson L, et al. (1998). "A regulatory role for RIP140 in nuclear receptor activation.". Mol. Endocrinol. 12 (6): 864–81. PMID 9626662. 
  • Eng FC, Barsalou A, Akutsu N, et al. (1998). "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain.". J. Biol. Chem. 273 (43): 28371–7. PMID 9774463. 
  • Lee CH, Chinpaisal C, Wei LN (1998). "Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2.". Mol. Cell. Biol. 18 (11): 6745–55. PMID 9774688. 
  • Miyata KS, McCaw SE, Meertens LM, et al. (1999). "Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor alpha and liver-X-receptor alpha.". Mol. Cell. Endocrinol. 146 (1-2): 69–76. PMID 10022764. 
  • Subramaniam N, Treuter E, Okret S (1999). "Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids.". J. Biol. Chem. 274 (25): 18121–7. PMID 10364267. 
  • Wiebel FF, Steffensen KR, Treuter E, et al. (1999). "Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer.". Mol. Endocrinol. 13 (7): 1105–18. PMID 10406462. 
  • Kumar MB, Tarpey RW, Perdew GH (1999). "Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs.". J. Biol. Chem. 274 (32): 22155–64. PMID 10428779. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
  • Wei LN, Hu X, Chandra D, et al. (2001). "Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing.". J. Biol. Chem. 275 (52): 40782–7. doi:10.1074/jbc.M004821200. PMID 11006275. 
  • Zilliacus J, Holter E, Wakui H, et al. (2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.". Mol. Endocrinol. 15 (4): 501–11. PMID 11266503. 
  • Mal A, Sturniolo M, Schiltz RL, et al. (2001). "A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program.". EMBO J. 20 (7): 1739–53. doi:10.1093/emboj/20.7.1739. PMID 11285237. 
  • Sugawara T, Abe S, Sakuragi N, et al. (2001). "RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1.". Endocrinology 142 (8): 3570–7. PMID 11459805. 
  • Vo N, Fjeld C, Goodman RH (2001). "Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.". Mol. Cell. Biol. 21 (18): 6181–8. PMID 11509661. 
  • Zennaro MC, Souque A, Viengchareun S, et al. (2002). "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action.". Mol. Endocrinol. 15 (9): 1586–98. PMID 11518808. 
  • Chen Y, Kerimo A, Khan S, Wei LN (2003). "Real-time analysis of molecular interaction of retinoid receptors and receptor-interacting protein 140 (RIP140).". Mol. Endocrinol. 16 (11): 2528–37. PMID 12403842. 

[edit] External links

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v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors