NPM3

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Nucleophosmin/nucleoplasmin, 3
Identifiers
Symbol(s) NPM3; PORMIN; TMEM123
External IDs OMIM: 606456 MGI: 894653 HomoloGene: 5083
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10360 18150
Ensembl ENSG00000107833 ENSMUSG00000056209
Uniprot O75607 Q3TAH3
Refseq NM_006993 (mRNA)
NP_008924 (protein)		 XM_978686 (mRNA)
XP_983780 (protein)
Location Chr 10: 103.53 - 103.53 Mb Chr 19: 45.8 - 45.8 Mb
Pubmed search [1] [2]

Nucleophosmin/nucleoplasmin, 3, also known as NPM3, is a human gene.[1]

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. It is highly homologous to the murine Npm3 gene. Based on the structural similarity of the human NPM3 gene product to nucleoplasmin and nucleophosmin, NPM3 may represent a new member of this gene family, and may share basic functions with the molecular chaperones.[1]

[edit] References

  1. ^ a b Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3.

[edit] Further reading

  • Philpott A, Krude T, Laskey RA (2000). "Nuclear chaperones.". Semin. Cell Dev. Biol. 11 (1): 7–14. doi:10.1006/scdb.1999.0346. PMID 10736259. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298. 
  • Shackleford GM, Ganguly A, MacArthur CA (2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones.". BMC Genomics 2 (1): 8. PMID 11722795. 
  • MacArthur CA, Shackleford GM (1997). "Npm3: a novel, widely expressed gene encoding a protein related to the molecular chaperones nucleoplasmin and nucleophosmin.". Genomics 42 (1): 137–40. doi:10.1006/geno.1997.4353. PMID 9177783. 
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