NPEPPS

From Wikipedia, the free encyclopedia

Aminopeptidase puromycin sensitive

Identifiers

NPEPPS; PSA; MP100

External IDs

OMIM: 606793 MGI: 1101358 HomoloGene: 36199

Gene ontology
Molecular Function:	• aminopeptidase activity • membrane alanyl aminopeptidase activity • metallopeptidase activity • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • cytosol
Biological Process:	• proteolysis

Orthologs

Human

Mouse

Refseq

XM_001128588 (mRNA)
XP_001128588 (protein)

NM_008942 (mRNA)
NP_032968 (protein)

Location

Chr 17: 42.96 - 43.06 Mb

Chr 11: 97.02 - 97.1 Mb

Pubmed search

[1]

[2]

Aminopeptidase puromycin sensitive, also known as NPEPPS, is a human gene.^[1]

This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle.^[1]

[edit] References

^ ^a ^b Entrez Gene: NPEPPS aminopeptidase puromycin sensitive.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Thompson MW, Hersh LB (2005). "Analysis of conserved residues of the human puromycin-sensitive aminopeptidase.". Peptides 24 (9): 1359–65. PMID 14706550.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bauer WO, Nanda I, Beck G, et al. (2001). "Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21.". Cytogenet. Cell Genet. 92 (3-4): 221–4. PMID 11435692.
de Gandarias JM, Irazusta J, Gil J, et al. (1999). "Ontogeny of puromycin-sensitive and insensitive aminopeptidase activities in several subcellular fractions of the rat brain.". Brain Res. Bull. 50 (4): 283–90. PMID 10582526.
Thompson MW, Tobler A, Fontana A, Hersh LB (1999). "Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase.". Biochem. Biophys. Res. Commun. 258 (2): 234–40. doi:10.1006/bbrc.1999.0604. PMID 10329370.
Huber G, Thompson A, Grüninger F, et al. (1999). "cDNA cloning and molecular characterization of human brain metalloprotease MP100: a beta-secretase candidate?". J. Neurochem. 72 (3): 1215–23. PMID 10037494.
Tobler AR, Constam DB, Schmitt-Gräff A, et al. (1997). "Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons.". J. Neurochem. 68 (3): 889–97. PMID 9048733.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Cussenot O, Berthon P, Cochand-Priollet B, et al. (1994). "Immunocytochemical comparison of cultured normal epithelial prostatic cells with prostatic tissue sections.". Exp. Cell Res. 214 (1): 83–92. doi:10.1006/excr.1994.1236. PMID 8082751.
Constam DB, Tobler AR, Rensing-Ehl A, et al. (1995). "Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization.". J. Biol. Chem. 270 (45): 26931–9. PMID 7592939.
McLellan S, Dyer SH, Rodriguez G, Hersh LB (1988). "Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases.". J. Neurochem. 51 (5): 1552–9. PMID 3171591.