NOV (gene)

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Nephroblastoma overexpressed gene
Identifiers
Symbol(s) NOV; CCN3; IGFBP9; NOVH
External IDs OMIM: 164958 MGI: 109185 HomoloGene: 1884
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4856 18133
Ensembl ENSG00000136999 ENSMUSG00000037362
Uniprot P48745 Q3U2X7
Refseq NM_002514 (mRNA)
NP_002505 (protein)		 NM_010930 (mRNA)
NP_035060 (protein)
Location Chr 8: 120.5 - 120.51 Mb Chr 15: 54.58 - 54.58 Mb
Pubmed search [1] [2]

Nephroblastoma overexpressed gene, also known as NOV, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: NOV nephroblastoma overexpressed gene.

[edit] Further reading

  • Perbal B (2007). "The CCN3 protein and cancer.". Adv. Exp. Med. Biol. 587: 23–40. PMID 17163153. 
  • Martinerie C, Viegas-Pequignot E, Guenard I, et al. (1993). "Physical mapping of human loci homologous to the chicken nov proto-oncogene.". Oncogene 7 (12): 2529–34. PMID 1334251. 
  • Martinerie C, Huff V, Joubert I, et al. (1994). "Structural analysis of the human nov proto-oncogene and expression in Wilms tumor.". Oncogene 9 (9): 2729–32. PMID 7520150. 
  • Martinerie C, Chevalier G, Rauscher FJ, Perbal B (1996). "Regulation of nov by WT1: a potential role for nov in nephrogenesis.". Oncogene 12 (7): 1479–92. PMID 8622864. 
  • Perbal B, Martinerie C, Sainson R, et al. (1999). "The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.". Proc. Natl. Acad. Sci. U.S.A. 96 (3): 869–74. PMID 9927660. 
  • Burren CP, Wilson EM, Hwa V, et al. (1999). "Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily.". J. Clin. Endocrinol. Metab. 84 (3): 1096–103. PMID 10084601. 
  • Perbal B (1999). "Nuclear localisation of NOVH protein: a potential role for NOV in the regulation of gene expression.". MP, Mol. Pathol. 52 (2): 84–91. PMID 10474687. 
  • Albrecht C, von Der Kammer H, Mayhaus M, et al. (2000). "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.". J. Biol. Chem. 275 (37): 28929–36. doi:10.1074/jbc.M003053200. PMID 10852911. 
  • Martinerie C, Gicquel C, Louvel A, et al. (2001). "Altered expression of novH is associated with human adrenocortical tumorigenesis.". J. Clin. Endocrinol. Metab. 86 (8): 3929–40. PMID 11502835. 
  • Manara MC, Perbal B, Benini S, et al. (2002). "The expression of ccn3(nov) gene in musculoskeletal tumors.". Am. J. Pathol. 160 (3): 849–59. PMID 11891184. 
  • Sakamoto K, Yamaguchi S, Ando R, et al. (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162. 
  • Li CL, Martinez V, He B, et al. (2002). "A role for CCN3 (NOV) in calcium signalling.". MP, Mol. Pathol. 55 (4): 250–61. PMID 12147716. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Thibout H, Martinerie C, Créminon C, et al. (2003). "Characterization of human NOV in biological fluids: an enzyme immunoassay for the quantification of human NOV in sera from patients with diseases of the adrenal gland and of the nervous system.". J. Clin. Endocrinol. Metab. 88 (1): 327–36. PMID 12519873. 
  • Lin CG, Leu SJ, Chen N, et al. (2003). "CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.". J. Biol. Chem. 278 (26): 24200–8. doi:10.1074/jbc.M302028200. PMID 12695522. 
  • Ellis PD, Metcalfe JC, Hyvönen M, Kemp PR (2003). "Adhesion of endothelial cells to NOV is mediated by the integrins alphavbeta3 and alpha5beta1.". J. Vasc. Res. 40 (3): 234–43. doi:10.1159/000071887. PMID 12902636. 
  • Laurent M, Martinerie C, Thibout H, et al. (2003). "NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism.". FASEB J. 17 (13): 1919–21. doi:10.1096/fj.02-1023fje. PMID 14519668. 
  • Lombet A, Planque N, Bleau AM, et al.. "CCN3 and calcium signaling." 1 (1): 1. doi:10.1186/1478-811X-1-1. PMID 14606958. 
  • Schild C, Trueb B (2004). "Three members of the connective tissue growth factor family CCN are differentially regulated by mechanical stress.". Biochim. Biophys. Acta 1691 (1): 33–40. doi:10.1016/j.bbamcr.2003.12.001. PMID 15053922. 
  • Gellhaus A, Dong X, Propson S, et al. (2004). "Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells.". J. Biol. Chem. 279 (35): 36931–42. doi:10.1074/jbc.M404073200. PMID 15181016. 
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