NOVA1

From Wikipedia, the free encyclopedia

Neuro-oncological ventral antigen 1

PDB rendering based on 1dt4.

Available structures: 1dt4, 1ec6, 2ann, 2anr

Identifiers

Symbol(s)

NOVA1; Nova-1

External IDs

OMIM: 602157 HomoloGene: 21296

Gene ontology
Molecular Function:	• mRNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• nuclear mRNA splicing, via spliceosome • synaptic transmission • locomotory behavior • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002515 (mRNA)
NP_002506 (protein)

XM_973643 (mRNA)
XP_978737 (protein)

Location

Chr 14: 25.98 - 26.14 Mb

n/a

Pubmed search

[1]

[2]

Neuro-oncological ventral antigen 1, also known as NOVA1, is a human gene.^[1]

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: NOVA1 neuro-oncological ventral antigen 1.

[edit] Further reading

Buckanovich RJ, Posner JB, Darnell RB (1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system.". Neuron 11 (4): 657-72. PMID 8398153.
Buckanovich RJ, Yang YY, Darnell RB (1996). "The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies.". J. Neurosci. 16 (3): 1114-22. PMID 8558240.
Buckanovich RJ, Darnell RB (1997). "The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.". Mol. Cell. Biol. 17 (6): 3194-201. PMID 9154818.
Lewis HA, Chen H, Edo C, et al. (1999). "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.". Structure 7 (2): 191-203. PMID 10368286.
Jensen KB, Dredge BK, Stefani G, et al. (2000). "Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability.". Neuron 25 (2): 359-71. PMID 10719891.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dredge BK, Darnell RB (2003). "Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer.". Mol. Cell. Biol. 23 (13): 4687-700. PMID 12808107.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ule J, Ule A, Spencer J, et al. (2005). "Nova regulates brain-specific splicing to shape the synapse.". Nat. Genet. 37 (8): 844-52. doi:10.1038/ng1610. PMID 16041372.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.