NOTCH1

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Notch homolog 1, translocation-associated (Drosophila)

PDB rendering based on 1pb5.

Available structures: 1pb5, 1toz, 1ymp, 1yyh, 2f8x, 2f8y, 2he0

Identifiers

Symbol(s)

NOTCH1; TAN1; hN1

External IDs

OMIM: 190198 MGI: 97363 HomoloGene: 32049

Gene ontology
Molecular Function:	• chromatin binding • receptor activity • calcium ion binding • protein binding
Cellular Component:	• nucleus • cytoplasm • membrane • integral to membrane
Biological Process:	• cell fate specification • epithelial to mesenchymal transition • sprouting angiogenesis • immune response • Notch signaling pathway • multicellular organismal development • determination of left/right symmetry • compartment specification • axonogenesis • foregut morphogenesis • endoderm development • heart development • positive regulation of cell proliferation • epidermis development • glial cell differentiation • keratinocyte differentiation • lung development • forebrain development • hair follicle morphogenesis • embryonic hindlimb morphogenesis • anagen • positive regulation of apoptosis • negative regulation of apoptosis • negative regulation of myoblast differentiation • negative regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • somatic stem cell division • neuron fate commitment • branching morphogenesis of a tube • regulation of epithelial cell proliferation • regulation of developmental process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017617 (mRNA)
NP_060087 (protein)

NM_008714 (mRNA)
NP_032740 (protein)

Location

Chr 9: 138.51 - 138.56 Mb

Chr 2: 26.28 - 26.33 Mb

Pubmed search

[1]

[2]

Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene.

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.^[1] A deficiency can be associated with bicuspid aortic valve.

[edit] References

^ Entrez Gene: NOTCH1 Notch homolog 1, translocation-associated (Drosophila).

[edit] Further reading

Artavanis-Tsakonas S, Rand MD, Lake RJ (1999). "Notch signaling: cell fate control and signal integration in development.". Science 284 (5415): 770–6. PMID 10221902.
Mumm JS, Kopan R (2001). "Notch signaling: from the outside in.". Dev. Biol. 228 (2): 151–65. doi:10.1006/dbio.2000.9960. PMID 11112321.
Allenspach EJ, Maillard I, Aster JC, Pear WS (2003). "Notch signaling in cancer.". Cancer Biol. Ther. 1 (5): 466–76. PMID 12496471.
Aster JC (2006). "Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.". Int. J. Hematol. 82 (4): 295–301. doi:10.1532/IJH97.05096. PMID 16298817.

[edit] External links

MeSH NOTCH1+protein,+human

This article on a gene on chromosome 9 is a stub. You can help Wikipedia by expanding it.

v • d • e Animal intercellular signaling peptides and proteins

Growth factors	Epidermal growth factor - Fibroblast growth factor (FGF1, FGF2, FGF4, FGF8, FGF10) - Nerve growth factor - Platelet-derived growth factor - Transforming growth factor (TGFα, TGFβ, TGFβ pathway)

Other	Hedgehog (Sonic hedgehog) - Integrin - JAK/STAT (JAK/STAT) - MAPK/ERK pathway (MAPK/ERK) - NF-κB - Notch (1, 2, 3) - p53 - Wnt (WNT4, Frzb)