NOLA1

From Wikipedia, the free encyclopedia

Nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)

Identifiers

External IDs

OMIM: 606468 MGI: 1930948 HomoloGene: 6104

Gene ontology
Molecular Function:	• cation channel activity • rRNA binding
Cellular Component:	• membrane fraction • nucleus • small nucleolar ribonucleoprotein complex
Biological Process:	• rRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018983 (mRNA)
NP_061856 (protein)

NM_026578 (mRNA)
NP_080854 (protein)

Location

Chr 4: 110.96 - 110.97 Mb

Chr 3: 129.82 - 129.82 Mb

Pubmed search

[1]

[2]

Nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs), also known as NOLA1, is a human gene.^[1]

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: NOLA1 nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs).

[edit] Further reading

Fujii Y, Zhao FX, Fu SC, et al. (1992). "Stable preparation of aldose reductase isoenzymes from human placenta.". Protein Expr. Purif. 2 (5-6): 420–5. PMID 1821816.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Ardell MD, Aragon I, Oliveira L, et al. (1996). "The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit.". FEBS Lett. 389 (2): 213–8. PMID 8766832.
Dragon F, Pogacić V, Filipowicz W (2000). "In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs.". Mol. Cell. Biol. 20 (9): 3037–48. PMID 10757788.
Pogacić V, Dragon F, Filipowicz W (2000). "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10.". Mol. Cell. Biol. 20 (23): 9028–40. PMID 11074001.
Pellizzoni L, Baccon J, Charroux B, Dreyfuss G (2001). "The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1.". Curr. Biol. 11 (14): 1079–88. PMID 11509230.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Whitehead SE, Jones KW, Zhang X, et al. (2003). "Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1.". J. Biol. Chem. 277 (50): 48087–93. doi:10.1074/jbc.M204551200. PMID 12244096.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wang C, Meier UT (2005). "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins.". EMBO J. 23 (8): 1857–67. doi:10.1038/sj.emboj.7600181. PMID 15044956.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.