NOL3

From Wikipedia, the free encyclopedia

Nucleolar protein 3 (apoptosis repressor with CARD domain)

Identifiers

NOL3; MYC; ARC; NOP; NOP30

External IDs

OMIM: 605235 MGI: 1925938 HomoloGene: 31208

Gene ontology
Molecular Function:	• RNA binding • identical protein binding
Cellular Component:	• intracellular • nucleus • nucleolus • mitochondrion • cytosol • sarcoplasm
Biological Process:	• mRNA processing • anti-apoptosis • RNA splicing • regulation of apoptosis

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003946 (mRNA)
NP_003937 (protein)

NM_030152 (mRNA)
NP_084428 (protein)

Location

n/a

Chr 8: 108.17 - 108.17 Mb

Pubmed search

[1]

[2]

Nucleolar protein 3 (apoptosis repressor with CARD domain), also known as NOL3, is a human gene.^[1]

[edit] References

^ Entrez Gene: NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain).

[edit] Further reading

Koseki T, Inohara N, Chen S, Núñez G (1998). "ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5156–60. PMID 9560245.
Stoss O, Schwaiger FW, Cooper TA, Stamm S (1999). "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c.". J. Biol. Chem. 274 (16): 10951–62. PMID 10196175.
Irie Y, Yamagata K, Gan Y, et al. (2000). "Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells.". J. Biol. Chem. 275 (4): 2647–53. PMID 10644725.
Li PF, Li J, Müller EC, et al. (2002). "Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC.". Mol. Cell 10 (2): 247–58. PMID 12191471.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ekhterae D, Platoshyn O, Zhang S, et al. (2003). "Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents.". Am. J. Physiol., Cell Physiol. 284 (6): C1405–10. doi:10.1152/ajpcell.00279.2002. PMID 12734105.
Nam YJ, Mani K, Ashton AW, et al. (2004). "Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.". Mol. Cell 15 (6): 901–12. doi:10.1016/j.molcel.2004.08.020. PMID 15383280.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jo DG, Jun JI, Chang JW, et al. (2004). "Calcium binding of ARC mediates regulation of caspase 8 and cell death.". Mol. Cell. Biol. 24 (22): 9763–70. doi:10.1128/MCB.24.22.9763-9770.2004. PMID 15509781.
Wang M, Qanungo S, Crow MT, et al. (2005). "Apoptosis repressor with caspase recruitment domain (ARC) is expressed in cancer cells and localizes to nuclei.". FEBS Lett. 579 (11): 2411–5. doi:10.1016/j.febslet.2005.03.040. PMID 15848180.
Mercier I, Vuolo M, Madan R, et al. (2005). "ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance.". Cell Death Differ. 12 (6): 682–6. doi:10.1038/sj.cdd.4401631. PMID 15861191.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Donath S, Li P, Willenbockel C, et al. (2006). "Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.". Circulation 113 (9): 1203–12. doi:10.1161/CIRCULATIONAHA.105.576785. PMID 16505176.
Nam YJ, Mani K, Wu L, et al. (2007). "The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant.". J. Biol. Chem. 282 (8): 5522–8. doi:10.1074/jbc.M609186200. PMID 17142452.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.