Nodal (protein)

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Nodal
Genetic data
Locus:	Chr. 10 q22.1
Gene code:	HUGO code:NODAL
Protein Structure/Function
Protein type:	cytokine
Functions:	cell differentiation
Domains:	TGFβ domain
Other
Taxa expressing:	Homo sapiens; homologs: many metazoan phyla
Cell types:	many
Subcellular localization:	Extracellular
Medical/Biotechnological data
Diseases:	Situs Ambiguus Online 'Mendelian Inheritance in Man' (OMIM) 601265
Database Links
Entrez:	4838
OMIM:	601265
RefSeq:	NM_018055
UniProt:	Q96S42

Nodal is a polypeptide member of the transforming growth factor beta superfamily of polypeptides. Like many other members of this superfamily, it is involved in cell differentiation. Nodal plays an essential role in mesoderm formation and axis specification. Nodal null mice die shortly after gastrulation^[1].

[edit] References

1. ^ Reissmann E,; Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH. (Aug 2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development". Genes Dev. 15 (15). Entrez PubMed 11485994. 

[edit] External links

• MeSH nodal+protein

v • d • e Cell signaling: TGF beta signaling pathway TGF beta superfamily of ligands TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other (Activin A and B/Inhibin A and B, Anti-müllerian hormone, Nodal) TGF beta receptors TGFBR1: Activin type 1 receptors (ACVR1, ACVR1B, ACVR1C) - ACVRL1 - BMPR1 (BMPR1A - BMPR1B) TGFBR2: Activin type 2 receptors (ACVR2A, ACVR2B) - AMHR2 - BMPR2 TGFBR3: betaglycan Transducers/SMAD R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4 Ligand Inhibitors Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1 Coreceptors BAMBI - Cripto Other SARA