NOD1

From Wikipedia, the free encyclopedia

Nucleotide-binding oligomerization domain containing 1

PDB rendering based on 2b1w.

Available structures: 2b1w, 2dbd, 2nsn

Identifiers

Symbol(s)

NOD1; CARD4; CLR7.1; NLRC1

External IDs

OMIM: 605980 MGI: 1341839 HomoloGene: 4440

Gene ontology
Molecular Function:	• nucleotide binding • signal transducer activity • protein binding • ATP binding • caspase activator activity • peptidoglycan binding
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• inflammatory response • intracellular signaling cascade • detection of bacterium • interleukin-8 biosynthetic process • defense response to bacterium • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • protein oligomerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006092 (mRNA)
NP_006083 (protein)

NM_172729 (mRNA)
NP_766317 (protein)

Location

Chr 7: 30.43 - 30.48 Mb

Chr 6: 54.85 - 54.9 Mb

Pubmed search

[1]

[2]

Nucleotide-binding oligomerization domain containing 1, also known as NOD1, is a human gene. NOD1 protein contains a caspase activation and recruitment domain (CARD).

[edit] Further reading

Martinon F, Tschopp J (2006). "NLRs join TLRs as innate sensors of pathogens.". Trends Immunol. 26 (8): 447–54. doi:10.1016/j.it.2005.06.004. PMID 15967716.
Strober W, Murray PJ, Kitani A, Watanabe T (2006). "Signalling pathways and molecular interactions of NOD1 and NOD2.". Nat. Rev. Immunol. 6 (1): 9–20. doi:10.1038/nri1747. PMID 16493424.
Bertin J, Nir WJ, Fischer CM, et al. (1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB.". J. Biol. Chem. 274 (19): 12955–8. PMID 10224040.
Inohara N, Koseki T, del Peso L, et al. (1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.". J. Biol. Chem. 274 (21): 14560–7. PMID 10329646.
Inohara N, Koseki T, Lin J, et al. (2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways.". J. Biol. Chem. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
Inohara N, Ogura Y, Chen FF, et al. (2001). "Human Nod1 confers responsiveness to bacterial lipopolysaccharides.". J. Biol. Chem. 276 (4): 2551–4. doi:10.1074/jbc.M009728200. PMID 11058605.
Chu ZL, Pio F, Xie Z, et al. (2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.". J. Biol. Chem. 276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID 11113115.
Yoo NJ, Park WS, Kim SY, et al. (2003). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1.". Biochem. Biophys. Res. Commun. 299 (4): 652–8. PMID 12459189.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Stehlik C, Hayashi H, Pio F, et al. (2003). "CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.". J. Biol. Chem. 278 (34): 31941–9. doi:10.1074/jbc.M300009200. PMID 12775719.
Girardin SE, Boneca IG, Carneiro LA, et al. (2003). "Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.". Science 300 (5625): 1584–7. doi:10.1126/science.1084677. PMID 12791997.
Hisamatsu T, Suzuki M, Podolsky DK (2003). "Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells.". J. Biol. Chem. 278 (35): 32962–8. doi:10.1074/jbc.M304355200. PMID 12813035.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Girardin SE, Travassos LH, Hervé M, et al. (2004). "Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.". J. Biol. Chem. 278 (43): 41702–8. doi:10.1074/jbc.M307198200. PMID 12871942.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kim JG, Lee SJ, Kagnoff MF (2004). "Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors.". Infect. Immun. 72 (3): 1487–95. PMID 14977954.
Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMID 15107016.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.