NLRP4

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NLR family, pyrin domain containing 4
Identifiers
Symbol(s) NLRP4; PAN2; CLR19.5; FLJ32126; NALP4; PYPAF4; RNH2
External IDs OMIM: 609645 MGI: 3056600 HomoloGene: 75315
Orthologs
Human Mouse
Entrez 147945 446099
Ensembl ENSG00000160505 ENSMUSG00000045693
Uniprot Q96MN2 n/a
Refseq NM_134444 (mRNA)
NP_604393 (protein)		 XM_987714 (mRNA)
XP_992808 (protein)
Location Chr 19: 61.04 - 61.09 Mb Chr 7: 23.01 - 23.07 Mb
Pubmed search [1] [2]

NLR family, pyrin domain containing 4, also known as NLRP4, is a human gene.[1]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: NLRP4 NLR family, pyrin domain containing 4.

[edit] Further reading

  • Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation.". Nat. Rev. Mol. Cell Biol. 4 (2): 95-104. doi:10.1038/nrm1019. PMID 12563287. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.". Biochem. J. 381 (Pt 1): 213-9. doi:10.1042/BJ20031506. PMID 15107016. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Grenier JM, Wang L, Manji GA, et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.". FEBS Lett. 530 (1-3): 73-8. PMID 12387869. 
  • Fiorentino L, Stehlik C, Oliveira V, et al. (2002). "A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta.". J. Biol. Chem. 277 (38): 35333-40. doi:10.1074/jbc.M200446200. PMID 12093792. 
  • Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.". J. Biol. Chem. 277 (33): 29874-80. doi:10.1074/jbc.M203915200. PMID 12019269. 
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