NLRC4

From Wikipedia, the free encyclopedia

NLR family, CARD domain containing 4

Identifiers

NLRC4; CARD12; CLAN; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; IPAF

External IDs

OMIM: 606831 MGI: 3036243 HomoloGene: 10924

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein binding • ATP binding • protein homodimerization activity
Cellular Component:	• intracellular
Biological Process:	• caspase activation • inflammatory response • detection of bacterium • defense response to bacterium • positive regulation of apoptosis • regulation of caspase activity • interleukin-1 beta secretion

Orthologs

Human

Mouse

n/a

Refseq

NM_021209 (mRNA)
NP_067032 (protein)

NM_001033367 (mRNA)
NP_001028539 (protein)

Location

Chr 2: 32.3 - 32.34 Mb

Chr 17: 74.33 - 74.35 Mb

Pubmed search

[1]

[2]

NLR family, CARD domain containing 4, also known as NLRC4, is a human gene.^[1]

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1 (CARD4; MIM 605980), and NOD2 (CARD15; MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NLRC4 NLR family, CARD domain containing 4.

[edit] Further reading

Geddes BJ, Wang L, Huang WJ, et al. (2001). "Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.". Biochem. Biophys. Res. Commun. 284 (1): 77–82. doi:10.1006/bbrc.2001.4928. PMID 11374873.
Poyet JL, Srinivasula SM, Tnani M, et al. (2001). "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.". J. Biol. Chem. 276 (30): 28309–13. doi:10.1074/jbc.C100250200. PMID 11390368.
Damiano JS, Stehlik C, Pio F, et al. (2001). "CLAN, a novel human CED-4-like gene.". Genomics 75 (1-3): 77–83. doi:10.1006/geno.2001.6579. PMID 11472070.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fu WN, Bertoni F, Kelsey SM, et al. (2003). "Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia.". Oncogene 22 (3): 451–5. doi:10.1038/sj.onc.1206147. PMID 12545166.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Agostini L, Martinon F, Burns K, et al. (2004). "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.". Immunity 20 (3): 319–25. PMID 15030775.
Damiano JS, Oliveira V, Welsh K, Reed JC (2004). "Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses.". Biochem. J. 381 (Pt 1): 213–9. doi:10.1042/BJ20031506. PMID 15107016.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Damiano JS, Newman RM, Reed JC (2004). "Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response.". J. Immunol. 173 (10): 6338–45. PMID 15528373.
Sadasivam S, Gupta S, Radha V, et al. (2005). "Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis.". Oncogene 24 (4): 627–36. doi:10.1038/sj.onc.1208201. PMID 15580302.
Lu C, Wang A, Wang L, et al. (2005). "Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation.". Biochem. Biophys. Res. Commun. 331 (4): 1114–9. doi:10.1016/j.bbrc.2005.04.027. PMID 15882992.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Thalappilly S, Sadasivam S, Radha V, Swarup G (2006). "Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.". FEBS J. 273 (12): 2766–78. doi:10.1111/j.1742-4658.2006.05293.x. PMID 16817903.