NLGN4X

From Wikipedia, the free encyclopedia

Neuroligin 4, X-linked

Identifiers

NLGN4X; ASPGX2; AUTSX2; HLNX; HNLX; KIAA1260; MGC22376; NLGN; NLGN4

External IDs

Gene ontology
Molecular Function:	• carboxylesterase activity • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_020742 (mRNA)
NP_065793 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr X: 5.82 - 6.16 Mb

n/a

Pubmed search

[1]

n/a

Neuroligin 4, X-linked, also known as NLGN4X, is a human gene.^[1]

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: NLGN4X neuroligin 4, X-linked.

[edit] Further reading

Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ....". Curr. Biol. 10 (17): R620–3. PMID 10996085.
Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95.". Science 277 (5331): 1511–5. PMID 9278515.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Bolliger MF, Frei K, Winterhalter KH, Gloor SM (2001). "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression.". Biochem. J. 356 (Pt 2): 581–8. PMID 11368788.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMID 12669065.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Laumonnier F, Bonnet-Brilhault F, Gomot M, et al. (2004). "X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family.". Am. J. Hum. Genet. 74 (3): 552–7. doi:10.1086/382137. PMID 14963808.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yan J, Oliveira G, Coutinho A, et al. (2005). "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients.". Mol. Psychiatry 10 (4): 329–32. doi:10.1038/sj.mp.4001629. PMID 15622415.
Blasi F, Bacchelli E, Pesaresi G, et al. (2006). "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (3): 220–1. doi:10.1002/ajmg.b.30287. PMID 16508939.
Talebizadeh Z, Lam DY, Theodoro MF, et al. (2006). "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism.". J. Med. Genet. 43 (5): e21. doi:10.1136/jmg.2005.036897. PMID 16648374.
Yamakawa H, Oyama S, Mitsuhashi H, et al. (2007). "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.". Biochem. Biophys. Res. Commun. 355 (1): 41–6. doi:10.1016/j.bbrc.2007.01.127. PMID 17292328.