NLGN2

From Wikipedia, the free encyclopedia

Neuroligin 2

Identifiers

NLGN2; KIAA1366

External IDs

OMIM: 606479 MGI: 2681835 HomoloGene: 69317

Gene ontology
Molecular Function:	• carboxylesterase activity • neurexin binding
Cellular Component:	• integral to membrane • synapse • postsynaptic membrane
Biological Process:	• synaptogenesis • cell-cell adhesion • intercellular junction maintenance

Orthologs

Human

Mouse

Refseq

NM_020795 (mRNA)
NP_065846 (protein)

NM_198862 (mRNA)
NP_942562 (protein)

Location

Chr 17: 7.25 - 7.26 Mb

Chr 11: 69.64 - 69.65 Mb

Pubmed search

[1]

[2]

Neuroligin 2, also known as NLGN2, is a human gene.^[1]

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.^[1]

[edit] References

^ ^a ^b Entrez Gene: NLGN2 neuroligin 2.

[edit] Further reading

Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ....". Curr. Biol. 10 (17): R620–3. PMID 10996085.
Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins.". J. Biol. Chem. 271 (5): 2676–82. PMID 8576240.
Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95.". Science 277 (5331): 1511–5. PMID 9278515.
Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198.
Philibert RA, Winfield SL, Sandhu HK, et al. (2000). "The structure and expression of the human neuroligin-3 gene.". Gene 246 (1-2): 303–10. PMID 10767552.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. PMID 10819331.
Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.". Cell 101 (6): 657–69. PMID 10892652.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMID 12669065.