NLGN1

From Wikipedia, the free encyclopedia

Neuroligin 1

Identifiers

NLGN1; KIAA1070; MGC45115

External IDs

OMIM: 600568 MGI: 2179435 HomoloGene: 56690

Gene ontology
Molecular Function:	• carboxylesterase activity • carboxylesterase activity • neurexin binding
Cellular Component:	• integral to plasma membrane • membrane • synapse
Biological Process:	• protein targeting • cell adhesion • synaptogenesis • synaptic vesicle targeting • calcium-dependent cell-cell adhesion • neuronal ion channel clustering • regulation of neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014932 (mRNA)
NP_055747 (protein)

NM_138666 (mRNA)
NP_619607 (protein)

Location

Chr 3: 174.81 - 175.48 Mb

Chr 3: 25.62 - 26.32 Mb

Pubmed search

[1]

[2]

Neuroligin 1, also known as NLGN1, is a human gene.^[1]

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.^[1]

[edit] See also

Neurexins: NRXN1, NRXN2, NRXN3

[edit] References

^ ^a ^b Entrez Gene: NLGN1 neuroligin 1.

[edit] Further reading

Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ....". Curr. Biol. 10 (17): R620-3. PMID 10996085.
Ichtchenko K, Hata Y, Nguyen T, et al. (1995). "Neuroligin 1: a splice site-specific ligand for beta-neurexins.". Cell 81 (3): 435-43. PMID 7736595.
Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins.". J. Biol. Chem. 271 (5): 2676-82. PMID 8576240.
Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95.". Science 277 (5331): 1511-5. PMID 9278515.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197-205. PMID 10470851.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143-50. PMID 10819331.
Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.". Cell 101 (6): 657-69. PMID 10892652.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Comoletti D, Flynn R, Jennings LL, et al. (2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.". J. Biol. Chem. 278 (50): 50497-505. doi:10.1074/jbc.M306803200. PMID 14522992.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Chubykin AA, Liu X, Comoletti D, et al. (2005). "Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.". J. Biol. Chem. 280 (23): 22365-74. doi:10.1074/jbc.M410723200. PMID 15797875.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194-8. doi:10.1038/nature04728. PMID 16641997.
Li X, Zhang J, Cao Z, et al. (2006). "Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin.". Protein Sci. 15 (9): 2149-58. doi:10.1110/ps.062087506. PMID 16882988.