NKX2-3

From Wikipedia, the free encyclopedia

NK2 transcription factor related, locus 3 (Drosophila)

Identifiers

NKX2-3; NKX2.3; NKX2C

External IDs

OMIM: 606727 MGI: 97348 HomoloGene: 17061

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • immune response • B cell differentiation

Orthologs

Human

Mouse

Refseq

NM_145285 (mRNA)
NP_660328 (protein)

NM_008699 (mRNA)
NP_032725 (protein)

Location

Chr 10: 101.28 - 101.29 Mb

Chr 19: 43.67 - 43.67 Mb

Pubmed search

[1]

[2]

NK2 transcription factor related, locus 3 (Drosophila), also known as NKX2-3, is a human gene.^[1]

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions. See Harvey (1996) for a review of the structure, regulation, function, and evolution of NK2 homeobox genes with an emphasis on their roles in heart development.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila).

[edit] Further reading

Harvey RP (1996). "NK-2 homeobox genes and heart development.". Dev. Biol. 178 (2): 203–16. doi:10.1006/dbio.1996.0212. PMID 8812123.
Price M, Lazzaro D, Pohl T, et al. (1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain.". Neuron 8 (2): 241–55. PMID 1346742.
Pabst O, Schneider A, Brand T, Arnold HH (1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development.". Dev. Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.
Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen.". Development 126 (10): 2215–25. PMID 10207146.
Phiel CJ, Gabbeta V, Parsons LM, et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues.". J. Biol. Chem. 276 (37): 34637–50. doi:10.1074/jbc.M105826200. PMID 11457859.
Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis.". Int. J. Dev. Biol. 46 (4): 415–22. PMID 12141427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.