NKX2-2

From Wikipedia, the free encyclopedia

NK2 transcription factor related, locus 2 (Drosophila)

Identifiers

NKX2-2; NKX2.2; NKX2B

External IDs

OMIM: 604612 MGI: 97347 HomoloGene: 1879

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • nervous system development • brain development • positive regulation of cell differentiation • positive regulation of transcription from RNA polymerase II promoter • cell development • neuron fate specification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002509 (mRNA)
NP_002500 (protein)

XM_001004391 (mRNA)
XP_001004391 (protein)

Location

Chr 20: 21.44 - 21.44 Mb

Chr 2: 146.87 - 146.88 Mb

Pubmed search

[1]

[2]

NK2 transcription factor related, locus 2 (Drosophila), also known as NKX2-2, is a human gene.^[1]

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.^[1]

[edit] References

^ ^a ^b Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila).

[edit] External links

http://atlasgeneticsoncology.org/Genes/NKX22ID44177ch20p11.html

[edit] Further reading

Price M, Lazzaro D, Pohl T, et al. (1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain.". Neuron 8 (2): 241–55. PMID 1346742.
Furuta H, Horikawa Y, Iwasaki N, et al. (1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.". Diabetes 47 (8): 1356–8. PMID 9703340.
Hessabi B, Schmidt I, Walther R (2000). "The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals.". Biochem. Biophys. Res. Commun. 270 (3): 695–700. doi:10.1006/bbrc.2000.2491. PMID 10772886.
Wang CC, Brodnicki T, Copeland NG, et al. (2000). "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.". Mamm. Genome 11 (6): 466–8. PMID 10818213.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sun T, Dong H, Wu L, et al. (2003). "Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.". J. Neurosci. 23 (29): 9547–56. PMID 14573534.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Smith R, Owen LA, Trem DJ, et al. (2006). "Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.". Cancer Cell 9 (5): 405–16. doi:10.1016/j.ccr.2006.04.004. PMID 16697960.
Pauls S, Zecchin E, Tiso N, et al. (2007). "Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts.". Dev. Biol. 304 (2): 875–90. doi:10.1016/j.ydbio.2007.01.024. PMID 17335795.