NKRF (gene)

From Wikipedia, the free encyclopedia

NF-kappaB repressing factor

Identifiers

NKRF; ITBA4; NRF

External IDs

OMIM: 300440 MGI: 1924536 HomoloGene: 84816

Gene ontology
Molecular Function:	• DNA binding • double-stranded RNA binding • specific transcriptional repressor activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • negative regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_017544 (mRNA)
NP_060014 (protein)

NM_029891 (mRNA)
NP_084167 (protein)

Location

Chr X: 118.61 - 118.62 Mb

Chr X: 33.32 - 33.33 Mb

Pubmed search

[1]

[2]

NF-kappaB repressing factor, also known as NKRF, is a human gene.^[1]

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.^[1]

[edit] References

^ ^a ^b Entrez Gene: NKRF NF-kappaB repressing factor.

[edit] Further reading

Frattini A, Faranda S, Bagnasco L, et al. (1997). "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25.". Gene 192 (2): 291–8. PMID 9224902.
Nourbakhsh M, Hauser H (2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB.". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMID 10562553.
Feng X, Guo Z, Nourbakhsh M, et al. (2002). "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. doi:10.1073/pnas.212306199. PMID 12381793.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jianfeng D, Feng J, Chaoneng J, et al. (2004). "Cloning of the correct full length cDNA of NF-kappaB-repressing factor.". Mol. Cells 16 (3): 397–401. PMID 14744032.
Niedick I, Froese N, Oumard A, et al. (2005). "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF.". J. Cell. Sci. 117 (Pt 16): 3447–58. doi:10.1242/jcs.01129. PMID 15226370.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dreikhausen U, Hiebenthal-Millow K, Bartels M, et al. (2005). "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor.". Mol. Cell. Biol. 25 (17): 7473–83. doi:10.1128/MCB.25.17.7473-7483.2005. PMID 16107696.
Fukuyama R, Ng KP, Cicek M, et al. (2007). "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.". Mol. Carcinog. 46 (5): 402–13. doi:10.1002/mc.20288. PMID 17186550.
Reboll MR, Oumard A, Gazdag AC, et al. (2007). "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.". RNA 13 (8): 1328–40. doi:10.1261/rna.545407. PMID 17592041.