Talk:Nitric oxide
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[edit] How is it ?
The opening paragraph talks about NO being toxic but, down in the biological effects section, it is described as a muscle relaxant, vaso-dialator, etc.
I'm not clear what the "toxic" part is. Is NO more or less toxic than, say, Valium? I don't think "toxic" is used appropriately, here; should probably be replaced with "undesirable."
[edit] Wrong link to the Hazardous Chemical Database
The link in the article pointed to nitrogen selenide. R6144 11:52, 21 August 2005 (UTC)
[edit] structure
The structure,DUde thats not right as in whether it's linear, and etc, dipolee moment, polarity, or whatnot... should be added
[edit] Physical properties
What are the physical properties of nitric oxide? Color? Smell? See Nitrogen dioxide for an example. Twilight Realm 20:30, 12 October 2005 (UTC)
[edit] Name
I thought the suffixes -ous and -ic weren't used anymore. Instead of nitrogen monoxide redirecting here, shouldn't this article redirect there? I have the same complaint with nitrous oxide. Twilight Realm 20:30, 12 October 2005 (UTC)
It's me again. Actually, I just checked the talk page for nitrous oxide, and they said the common name should be used. So, as long as nitric oxide is the common name, I guess that's ok. But first I'd like some confirmation that this is the common name. Twilight Realm 20:30, 12 October 2005 (UTC)
Yet another edit. Go here to see my proposal on this topic. Twilight Realm 21:05, 12 October 2005 (UTC)
Environmental: While the article states that NO and NO2 contribute to the destruction of the ozone layer, this misses the important contribution of NO to ground level ozone production.
[edit] Bio-part of this article should be relocated?
A lot of nice bio-NO content in the present article, but it may be redundant with or more suitable for Endothelium-derived relaxing factor and signal transduction. IMHO.--Smokefoot 02:26, 28 August 2006 (UTC)
[edit] Chembox
I'm putting the old chembox here while I graft its info onto the new chembox.
Ben 20:13, 16 October 2006 (UTC)
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General |
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| Name | Nitrogen monoxide |
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| Chemical formula | NO |
| Appearance | Colorless gas |
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Physical |
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| Formula weight | 30.0 amu |
| Melting point | 109 K (-164 °C) |
| Boiling point | 121 K (-152 °C) |
| Density | 1.3 ×103 kg/m3 (liquid) |
| Solubility | 0.0056 g in 100g water |
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Thermochemistry |
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| ΔfH0gas | 90 kJ/mol |
| ΔfH0liquid | 87.7 kJ/mol |
| S0gas, 1 bar | 211 J/mol·K |
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Safety |
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| Ingestion | Used for medicinal purposes but has side effects and dangerous in overdose |
| Inhalation | Dangerous, may be fatal. |
| Skin | Irritant. |
| Eyes | May cause irritation |
| More info | Hazardous Chemical Database |
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SI units were used where possible. Unless otherwise stated, standard conditions were used. |
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[edit] Bonding
How does the oxygen bond to the nitrogen? I´ve learned the oxygen can only have two covalent bonds, and the nitrogen, three. If two electrons from each are in the bond, the nitrogen doesn´t have its octet complete. What happens, then? A.Z. 14:51, 2 November 2006 (UTC)
That's why it's considered a free radical. It has one electron which is usually shared along with another molecule's electron to form it's third bond, but instead there is no third bond and it is deemed a free radical. It doesn't like to be this way, that is why it is so reactive. You can see this in the structure you included with the single electron on top. 149.169.51.9 22:43, 19 December 2006 (UTC) Andrea
[edit] Minoxidil works through ATP-sensitive potassium channels
Minoxidil apparently works directly on ATP-sensitive potassium channels without stimulating cGMP or PKG. The Potassium hypothesis for hair growth has been supported by numerous agents that influence potassium flux altering hair growth. It appears to be direct on the dermal papillae and potassium channels, and not increased blood flow or PKG phosporylation cell signalling events. As far as NO and the hair follicle it is inducible by androgens and is present in follicle melanocytes (role in greying maybe) but I don't think it is exactly clear what role it plays (maybe associated with hair loss). I don't think the statements are accurate and upto date or appropriate for the topic of NO. Minoxidil maybe contains the molecular structure of NO but there is no proof that is how it effects hair growth. GetAgrippa 05:06, 4 February 2007 (UTC)
This sort of reminds me of some antidepressants as they were designed to modulate neutransmitter reuptake, etc. , yet the real function may have to do with neurogenesis in the hippocampus. Anyways, although minoxidil contains the NO structure the evidence doesn't support the effects on hair growth are NO mediated. GetAgrippa 03:22, 5 February 2007 (UTC)
[edit] N-O bond length
Bond length is given as 115 ppm. Anyone knows the source of this info? Preferably a scientfic paper. Thanks. -RTyg 131.130.30.233 14:35, 17 April 2007 (UTC)
[edit] NO-Xplode Redirect
NO-Xplode is a nutritional supplement, why does it redirect to Nitric Oxide? The page does not even mention the supplement. —The preceding unsigned comment was added by DaMenace123 (talk • contribs) 16:07, 16 May 2007 (UTC).
Vasodilation involves an increase in blood flow, the article states that dialtion induces a decrease in blood-flow, which is incorrect. Dilation does however create a decrease in blood pressure.
