Nitric oxide synthase 2A

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Nitric oxide synthase 2A (inducible, hepatocytes)
PDB rendering based on 1nsi.
Available structures: 1nsi, 2nsi, 4nos
Identifiers
Symbol(s)	NOS2A; NOS; HEP-NOS; INOS; NOS2
External IDs	OMIM: 163730 MGI: 97361 HomoloGene: 55473
Gene ontology Molecular Function: • nitric-oxide synthase activity • iron ion binding • calcium ion binding • calmodulin binding • zinc ion binding • electron carrier activity • FMN binding • heme binding • protein homodimerization activity • FAD binding • NADP binding Cellular Component: • cytoplasm • cytosol • cortical cytoskeleton • perinuclear region of cytoplasm Biological Process: • response to hypoxia • electron transport • superoxide metabolic process • nitric oxide biosynthetic process • inflammatory response • defense response to bacterium
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4843	18126
Ensembl	ENSG00000007171	n/a
Uniprot	P35228	n/a
Refseq	NM_000625 (mRNA) NP_000616 (protein)	XM_001001508 (mRNA) XP_001001508 (protein)
Location	Chr 17: 23.11 - 23.15 Mb	n/a
Pubmed search	[1]	[2]

Nitric oxide synthase 2A (inducible, hepatocytes), also known as NOS2A, is a human gene.

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[1]

[edit] References

v • d • e Metabolism: amino acid metabolism - neurotransmitter enzymes histidine→histamine anabolism: Histidine decarboxylase catabolism: Histamine N-methyltransferase - Amine oxidase tyrosine→dopamine→epinephrine anabolism: Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase catabolism: Catechol-O-methyl transferase - Monoamine oxidase glutamate→GABA anabolism: Glutamate decarboxylase catabolism: 4-aminobutyrate aminotransferase tryptophan→serotonin→melatonin Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - Acetylserotonin O-methyltransferase arginine→NO Nitric oxide synthase (NOS1, NOS2A, NOS3) see also intermediates

v • d • e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14) 1.14.11 - 2-oxoglutarate Prolyl hydroxylase - Lysyl hydroxylase 1.14.13 - NADH or NADPH Flavin-containing monooxygenase - Nitric oxide synthase (NOS1, NOS2A, NOS3) - Cholesterol 7 alpha-hydroxylase - Methane monooxygenase - 3A4 -51A1 1.14.14 - reduced flavin or flavoprotein 19A1 - 2D6 - 2E1 1.14.15 - reduced iron-sulfur protein 11B1 - 11B2 - 11A1 1.14.16 - reduced pteridine Phenylalanine hydroxylase - Tyrosine hydroxylase - Tryptophan hydroxylase 1.14.17 - reduced ascorbate Dopamine beta hydroxylase 1.14.18-19 - other Tyrosinase - Stearoyl-CoA desaturase-1 1.14.99 - miscellaneous Cyclooxygenase - Heme oxygenase (HMOX1) - Squalene monooxygenase - 17A1 - 21A2