Nicotinate-nucleotide diphosphorylase (carboxylating)

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In enzymology, a nicotinate-nucleotide diphosphorylase (carboxylating) (EC 2.4.2.19) is an enzyme that catalyzes the chemical reaction

nicotinate D-ribonucleotide + diphosphate + CO₂ $\rightleftharpoons$ pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate

The 3 substrates of this enzyme are nicotinate D-ribonucleotide, diphosphate, and CO₂, whereas its two products are pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating). Other names in common use include quinolinate phosphoribosyltransferase (decarboxylating), quinolinic acid phosphoribosyltransferase, QAPRTase, NAD+ pyrophosphorylase, nicotinate mononucleotide pyrophosphorylase (carboxylating), and quinolinic phosphoribosyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1QAP, 1QPN, 1QPO, 1QPQ, 1QPR, 1X1O, 2B7N, 2B7P, and 2B7Q.

[edit] References

IUBMB entry for 2.4.2.19
BRENDA references for 2.4.2.19 (Recommended.)
PubMed references for 2.4.2.19
PubMed Central references for 2.4.2.19
Google Scholar references for 2.4.2.19
GHOLSON RK, UEDA I, OGASAWARA N, HENDERSON LM (1964). "THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER". J. Biol. Chem. 239: 1208–14. PMID 14165928.
Packman PM, Jakoby WB (1965). "Crystalline quinolinate phosphoribosyltransferase". J. Biol. Chem. 240: 4107–8. PMID 5320648.