Nicotinate-nucleotide adenylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) is an enzyme that catalyzes the chemical reaction

ATP + nicotinate ribonucleotide diphosphate + deamido-NAD⁺

Thus, the two substrates of this enzyme are ATP and nicotinate ribonucleotide, whereas its two products are diphosphate and deamido-NAD+.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:nicotinate-ribonucleotide adenylyltransferase. Other names in common use include deamido-NAD+ pyrophosphorylase, nicotinate mononucleotide adenylyltransferase, deamidonicotinamide adenine dinucleotide pyrophosphorylase, NaMN-ATase, and nicotinic acid mononucleotide adenylyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1K4K, 1K4M, 1KAM, 1KAQ, 1YUL, 1YUM, 1YUN, 2H29, and 2H2A.

[edit] References

• IUBMB entry for 2.7.7.18
• BRENDA references for 2.7.7.18 (Recommended.)
• PubMed references for 2.7.7.18
• PubMed Central references for 2.7.7.18
• Google Scholar references for 2.7.7.18
• IMSANDE J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli". J. Biol. Chem. 236: 1494–7. PMID 13717628. 

[edit] External links

The CAS registry number for this enzyme class is 9026-98-6.

• IUBMB entry for 2.7.7.18

• KEGG entry for 2.7.7.18

• BRENDA entry for 2.7.7.18

• NiceZyme view of 2.7.7.18

• EC2PDB: PDB structures for 2.7.7.18

• PRIAM entry for 2.7.7.18

• PUMA2 entry for 2.7.7.18

• IntEnz: Integrated Enzyme entry for 2.7.7.18

• MetaCyc entry for 2.7.7.18

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004515: nicotinate-nucleotide adenylyltransferase

• AMIGO entry for GO code 0004515: nicotinate-nucleotide adenylyltransferase