Nicotinamide phosphoribosyltransferase
From Wikipedia, the free encyclopedia
In enzymology, a nicotinamide phosphoribosyltransferase (EC 2.4.2.12) is an enzyme that catalyzes the chemical reaction
- nicotinamide D-ribonucleotide + diphosphate
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Thus, the two substrates of this enzyme are nicotinamide D-ribonucleotide and diphosphate, whereas its two products are nicotinamide and 5-phospho-alpha-D-ribose 1-diphosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase. Other names in common use include NMN pyrophosphorylase, nicotinamide mononucleotide pyrophosphorylase, nicotinamide mononucleotide synthetase, and NMN synthetase. This enzyme participates in nicotinate and nicotinamide metabolism.
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[edit] Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2G95, 2G96, 2G97, 2GVG, 2GVJ, 2GVL, 2H3B, and 2H3D.
[edit] References
- IUBMB entry for 2.4.2.12
- BRENDA references for 2.4.2.12 (Recommended.)
- PubMed references for 2.4.2.12
- PubMed Central references for 2.4.2.12
- Google Scholar references for 2.4.2.12
- Preiss J and Handler P (1957). "Enzymatic synthesis of nicotinamide mononucleotide". J. Biol. Chem. 225: 759–770.
[edit] External links
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- The CAS registry number for this enzyme class is 9030-27-7.
[edit] Gene Ontology (GO) codes
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