Nicotinamide-nucleotide adenylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) is an enzyme that catalyzes the chemical reaction

ATP + nicotinamide ribonucleotide diphosphate + NAD⁺

Thus, the two substrates of this enzyme are ATP and nicotinamide ribonucleotide, whereas its two products are diphosphate and NAD⁺.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:nicotinamide-nucleotide adenylyltransferase. Other names in common use include NAD+ pyrophosphorylase, adenosine triphosphate-nicotinamide mononucleotide transadenylase, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyltransferase, and NMN adenylyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism. The human version of this protein is NMNAT1.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1EJ2, 1GZU, 1HYB, 1KKU, 1KQN, 1KQO, 1KR2, 1M8F, 1M8G, 1M8J, and 1M8K.

[edit] References

• IUBMB entry for 2.7.7.1
• BRENDA references for 2.7.7.1 (Recommended.)
• PubMed references for 2.7.7.1
• PubMed Central references for 2.7.7.1
• Google Scholar references for 2.7.7.1
• ATKINSON MR, JACKSON JF, MORTON RK (1961). "Nicotinamide mononucleotide adenylyltransferase of pig-liver nuclei The effects of nicotinamide mononucleotide concentration and pH on dinucleotide synthesis". Biochem. J. 80: 318–23. PMID 13684981. 
• Dahmen W, Webb B, Preiss J (1967). "The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast". Arch. Biochem. Biophys. 120: 440–50. PMID 4291828. 
• Kornberg A and Pricer WE (1951). "Enzymatic cleavage of diphosphopyridine nucleotide with radioactive pyrophosphate". J. Biol. Chem. 191: 535–541. 

[edit] External links

The CAS registry number for this enzyme class is 9032-70-6.

• IUBMB entry for 2.7.7.1

• KEGG entry for 2.7.7.1

• BRENDA entry for 2.7.7.1

• NiceZyme view of 2.7.7.1

• EC2PDB: PDB structures for 2.7.7.1

• PRIAM entry for 2.7.7.1

• PUMA2 entry for 2.7.7.1

• IntEnz: Integrated Enzyme entry for 2.7.7.1

• MetaCyc entry for 2.7.7.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0000309: nicotinamide-nucleotide adenylyltransferase

• AMIGO entry for GO code 0000309: nicotinamide-nucleotide adenylyltransferase