NHP2L1

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NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
PDB rendering based on 1e7k.
Available structures: 1e7k, 2ozb
Identifiers
Symbol(s) NHP2L1; NHPX; OTK27; SNU13
External IDs OMIM: 601304 HomoloGene: 3672
Orthologs
Human Mouse
Entrez 4809 n/a


Refseq NM_001003796 (mRNA)
NP_001003796 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae), also known as NHP2L1, is a human gene.[1]

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae).

[edit] Further reading

  • Saito H, Fujiwara T, Shin S, et al. (1997). "Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2.". Cytogenet. Cell Genet. 72 (2-3): 191-3. PMID 8978773. 
  • Nottrott S, Hartmuth K, Fabrizio P, et al. (2000). "Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA.". EMBO J. 18 (21): 6119-33. doi:10.1093/emboj/18.21.6119. PMID 10545122. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208. 
  • Chang MS, Sasaki H, Campbell MS, et al. (2000). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation.". J. Biol. Chem. 274 (51): 36544-9. PMID 10593953. 
  • Vidovic I, Nottrott S, Hartmuth K, et al. (2001). "Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment.". Mol. Cell 6 (6): 1331-42. PMID 11163207. 
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298. 
  • Leung AK, Lamond AI (2002). "In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles.". J. Cell Biol. 157 (4): 615-29. doi:10.1083/jcb.200201120. PMID 12011111. 
  • Watkins NJ, Dickmanns A, Lührmann R (2003). "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.". Mol. Cell. Biol. 22 (23): 8342-52. PMID 12417735. 
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100-9. doi:10.1091/mbc.E02-05-0271. PMID 12429849. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77-83. doi:10.1038/nature03207. PMID 15635413. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
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