NHLH1

From Wikipedia, the free encyclopedia

Nescient helix loop helix 1

Identifiers

NHLH1; HEN1; NSCL; NSCL1

External IDs

OMIM: 162360 MGI: 98481 HomoloGene: 4089

Gene ontology
Molecular Function:	• DNA binding • transcription regulator activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • central nervous system development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005598 (mRNA)
NP_005589 (protein)

NM_010916 (mRNA)
NP_035046 (protein)

Location

Chr 1: 158.6 - 158.61 Mb

Chr 1: 173.89 - 173.89 Mb

Pubmed search

[1]

[2]

Nescient helix loop helix 1, also known as NHLH1, is a human gene.^[1]

The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NHLH1 nescient helix loop helix 1.

[edit] Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Manetopoulos C, Hansson A, Karlsson J, et al. (2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1.". Biochem. Biophys. Res. Commun. 307 (4): 891-9. PMID 12878195.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bao J, Talmage DA, Role LW, Gautier J (2000). "Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins.". Development 127 (2): 425-35. PMID 10603358.
Begley CG, Lipkowitz S, Göbel V, et al. (1992). "Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 38-42. PMID 1729708.
Brown L, Espinosa R, Le Beau MM, et al. (1992). "HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma.". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8492-6. PMID 1528853.
Lipkowitz S, Göbel V, Varterasian ML, et al. (1992). "A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system.". J. Biol. Chem. 267 (29): 21065-71. PMID 1328219.