NHEJ1

From Wikipedia, the free encyclopedia

Nonhomologous end-joining factor 1

Identifiers

NHEJ1; FLJ12610; XLF

External IDs

MGI: 1922820 HomoloGene: 11714

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus
Biological Process:	• DNA repair • double-strand break repair via nonhomologous end joining • central nervous system development • response to ionizing radiation • B cell differentiation • T cell differentiation • positive regulation of ligase activity

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_024782 (mRNA)
NP_079058 (protein)

XM_992746 (mRNA)
XP_997840 (protein)

Location

n/a

Chr 1: 74.9 - 74.98 Mb

Pubmed search

[1]

[2]

Nonhomologous end-joining factor 1, also known as NHEJ1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NHEJ1 nonhomologous end-joining factor 1.

[edit] Further reading

Pastwa E, Malinowski M (2007). "Non-homologous DNA end joining in anticancer therapy.". Current cancer drug targets 7 (3): 243-50. PMID 17504121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Dai Y, Kysela B, Hanakahi LA, et al. (2003). "Nonhomologous end joining and V(D)J recombination require an additional factor.". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2462-7. doi:10.1073/pnas.0437964100. PMID 12604777.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Buck D, Malivert L, de Chasseval R, et al. (2006). "Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.". Cell 124 (2): 287-99. doi:10.1016/j.cell.2005.12.030. PMID 16439204.
Ahnesorg P, Smith P, Jackson SP (2006). "XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.". Cell 124 (2): 301-13. doi:10.1016/j.cell.2005.12.031. PMID 16439205.
Callebaut I, Malivert L, Fischer A, et al. (2006). "Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.". J. Biol. Chem. 281 (20): 13857-60. doi:10.1074/jbc.C500473200. PMID 16571728.
Revy P, de Villartay JP (2006). "[Cernunnos, a novel DNA repair factor essential for the immune system]". Med Sci (Paris) 22 (6-7): 569-70. PMID 16828027.
Cantagrel V, Lossi AM, Lisgo S, et al. (2007). "Truncation of NHEJ1 in a patient with polymicrogyria.". Hum. Mutat. 28 (4): 356-64. doi:10.1002/humu.20450. PMID 17191205.
Lu H, Pannicke U, Schwarz K, Lieber MR (2007). "Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity.". J. Biol. Chem. 282 (15): 11155-62. doi:10.1074/jbc.M609904200. PMID 17317666.
Tsai CJ, Kim SA, Chu G (2007). "Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends.". Proc. Natl. Acad. Sci. U.S.A. 104 (19): 7851-6. doi:10.1073/pnas.0702620104. PMID 17470781.
Deshpande RA, Wilson TE (2007). "Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4.". DNA Repair (Amst.) 6 (10): 1507-16. doi:10.1016/j.dnarep.2007.04.014. PMID 17567543.
Wu PY, Frit P, Malivert L, et al. (2007). "Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.". J. Biol. Chem. 282 (44): 31937-43. doi:10.1074/jbc.M704554200. PMID 17720816.