NFX1

From Wikipedia, the free encyclopedia

Nuclear transcription factor, X-box binding 1

Identifiers

NFX1; DKFZp779G2416; MGC20369; NFX2

External IDs

OMIM: 603255 MGI: 1921414 HomoloGene: 1875

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • ubiquitin cycle • inflammatory response

Orthologs

Human

Mouse

n/a

Refseq

NM_002504 (mRNA)
NP_002495 (protein)

NM_023739 (mRNA)
NP_076228 (protein)

Location

Chr 9: 33.28 - 33.36 Mb

Chr 4: 41.16 - 41.21 Mb

Pubmed search

[1]

[2]

Nuclear transcription factor, X-box binding 1, also known as NFX1, is a human gene.^[1]

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1.

[edit] Further reading

Hume CR, Lee JS (1990). "Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors.". Hum. Immunol. 26 (4): 288–309. PMID 2511169.
Song Z, Krishna S, Thanos D, et al. (1994). "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor.". J. Exp. Med. 180 (5): 1763–74. PMID 7964459.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. PMID 10500182.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Saito K, Fujiwara T, Katahira J, et al. (2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD.". Biochem. Biophys. Res. Commun. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. PMID 15358174.
Gewin L, Myers H, Kiyono T, Galloway DA (2004). "Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex.". Genes Dev. 18 (18): 2269–82. doi:10.1101/gad.1214704. PMID 15371341.
Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, et al. (2007). "NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.". J. Virol. 81 (8): 3786–96. doi:10.1128/JVI.02007-06. PMID 17267499.