NFKBIZ
From Wikipedia, the free encyclopedia
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Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
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| Identifiers | |||||
| Symbol(s) | NFKBIZ; FLJ30225; FLJ34463; IKBZ; INAP; MAIL | ||||
| External IDs | OMIM: 608004 MGI: 1931595 HomoloGene: 12734 | ||||
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| Orthologs | |||||
| Human | Mouse | ||||
| Entrez | 64332 | 80859 | |||
| Ensembl | ENSG00000144802 | ENSMUSG00000035356 | |||
| Refseq | NM_001005474 (mRNA) NP_001005474 (protein) |
NM_030612 (mRNA) NP_085115 (protein) |
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| Location | Chr 3: 103.05 - 103.06 Mb | Chr 16: 55.74 - 55.76 Mb | |||
| Pubmed search | [1] | [2] | |||
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta, also known as NFKBIZ, is a human gene.[1]
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.[1]
[edit] References
[edit] Further reading
- Haruta H, Kato A, Todokoro K (2001). "Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs.". J. Biol. Chem. 276 (16): 12485–8. doi:. PMID 11278262.
- Yamazaki S, Muta T, Takeshige K (2001). "A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei.". J. Biol. Chem. 276 (29): 27657–62. doi:. PMID 11356851.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Eto A, Muta T, Yamazaki S, Takeshige K (2003). "Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta.". Biochem. Biophys. Res. Commun. 301 (2): 495–501. PMID 12565889.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
- Yamamoto M, Yamazaki S, Uematsu S, et al. (2004). "Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.". Nature 430 (6996): 218–22. doi:. PMID 15241416.
- Yamazaki S, Muta T, Matsuo S, Takeshige K (2005). "Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization.". J. Biol. Chem. 280 (2): 1678–87. doi:. PMID 15522867.
- Motoyama M, Yamazaki S, Eto-Kimura A, et al. (2005). "Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein.". J. Biol. Chem. 280 (9): 7444–51. doi:. PMID 15618216.
- Totzke G, Essmann F, Pohlmann S, et al. (2006). "A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.". J. Biol. Chem. 281 (18): 12645–54. doi:. PMID 16513645.
- Cowland JB, Muta T, Borregaard N (2006). "IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta.". J. Immunol. 176 (9): 5559–66. PMID 16622025.
- Matsuo S, Yamazaki S, Takeshige K, Muta T (2007). "Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation.". Biochem. J. 405 (3): 605–15. doi:. PMID 17447895.
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