NFKBIL1

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Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Identifiers
Symbol(s) NFKBIL1; IKBL; LST1; NFKBIL
External IDs OMIM: 601022 MGI: 1340031 HomoloGene: 3671
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4795 18038
Ensembl ENSG00000168593 ENSMUSG00000042419
Uniprot Q9UBC1 Q3V006
Refseq NM_005007 (mRNA)
NP_004998 (protein)		 XM_001000143 (mRNA)
XP_001000143 (protein)
Location Chr c6_COX: 31.65 - 31.66 Mb Chr 17: 34.83 - 34.84 Mb
Pubmed search [1] [2]

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1, also known as NFKBIL1, is a human gene.[1]

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6.[1]

[edit] References

  1. ^ a b Entrez Gene: NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1.

[edit] Further reading

  • Albertella MR, Campbell RD (1994). "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins.". Hum. Mol. Genet. 3 (5): 793-9. PMID 8081366. 
  • Iris FJ, Bougueleret L, Prieur S, et al. (1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.". Nat. Genet. 3 (2): 137-45. doi:10.1038/ng0293-137. PMID 8499947. 
  • Shiina T, Tamiya G, Oka A, et al. (1998). "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region.". Genomics 47 (3): 372-82. doi:10.1006/geno.1997.5114. PMID 9480751. 
  • Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.". J. Immunol. 162 (8): 4745-54. PMID 10202016. 
  • Allcock RJ, Christiansen FT, Price P (1999). "The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15.". Immunogenetics 49 (7-8): 660-5. PMID 10369924. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Okamoto K, Makino S, Yoshikawa Y, et al. (2003). "Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.". Am. J. Hum. Genet. 72 (2): 303-12. PMID 12509789. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404. 
  • Lin CH, Cho CL, Tsai WC, et al. (2006). "Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis.". Immunol. Lett. 105 (2): 193-7. doi:10.1016/j.imlet.2006.03.003. PMID 16644022. 
  • Glas J, Török HP, Tonenchi L, et al. (2007). "Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes.". Inflamm. Bowel Dis. 12 (7): 606-11. doi:10.1097/01.ibd.0000225346.23765.6b. PMID 16804398. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
  • Koch W, Hoppmann P, Michou E, et al. (2007). "Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.". Hum. Mol. Genet. 16 (15): 1821-7. doi:10.1093/hmg/ddm130. PMID 17517687. 
  • Ramasawmy R, Faé KC, Cunha-Neto E, et al. (2007). "Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals.". Mol. Immunol. 45 (1): 283-8. doi:10.1016/j.molimm.2007.04.015. PMID 17544510. 
  • Kariz S, Milutinović A, Bregar D, et al. (2007). "The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes.". Collegium antropologicum 31 (2): 503-7. PMID 17847930. 
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