NFKB1

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Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), also known as NFKB1, is a human gene.

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
PDB rendering based on 1bfs.
Available structures: 1bfs, 1ikn, 1le5, 1le9, 1lei, 1nfi, 1nfk, 1ooa, 1svc, 1u36, 1u3j, 1u3y, 1u3z, 1u41, 1u42, 1vkx, 2dbf, 2i9t
Identifiers
Symbol(s) NFKB1; DKFZp686C01211; EBP-1; KBF1; MGC54151; NF-kappa-B; NFKB-p105; NFKB-p50
External IDs OMIM: 164011 MGI: 97312 HomoloGene: 2971
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4790 18033
Ensembl ENSG00000109320 ENSMUSG00000028163
Uniprot P19838 P25799
Refseq NM_003998 (mRNA)
NP_003989 (protein)		 NM_008689 (mRNA)
NP_032715 (protein)
Location Chr 4: 103.64 - 103.76 Mb Chr 3: 135.29 - 135.61 Mb
Pubmed search [1] [2]

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.[1]


[edit] References

  1. ^ Entrez Gene: NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105).

[edit] Further reading

  • Baldwin AS (1996). "The NF-kappa B and I kappa B proteins: new discoveries and insights.". Annu. Rev. Immunol. 14: 649–83. doi:10.1146/annurev.immunol.14.1.649. PMID 8717528. 
  • Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227–30. PMID 8997639. 
  • Chen F, Castranova V, Shi X, Demers LM (1999). "New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases.". Clin. Chem. 45 (1): 7–17. PMID 9895331. 
  • Bottex-Gauthier C, Pollet S, Favier A, Vidal DR (2002). "[The Rel/NF-kappa-B transcription factors: complex role in cell regulation]". Pathol. Biol. 50 (3): 204–11. PMID 11980335. 
  • Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development.". Leukemia 16 (6): 1053–68. doi:10.1038/sj.leu.2402482. PMID 12040437. 
  • Sun Z, Andersson R (2003). "NF-kappaB activation and inhibition: a review.". Shock 18 (2): 99–106. PMID 12166787. 
  • Mercurio AM (2003). "Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way.". Cancer Cell 3 (3): 201–2. PMID 12676577. 
  • Sun SC, Xiao G (2004). "Deregulation of NF-kappaB and its upstream kinases in cancer.". Cancer Metastasis Rev. 22 (4): 405–22. PMID 12884915. 
  • Kucharczak J, Simmons MJ, Fan Y, Gélinas C (2004). "To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis.". Oncogene 22 (56): 8961–82. doi:10.1038/sj.onc.1207230. PMID 14663476. 
  • Suh J, Rabson AB (2004). "NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?". J. Cell. Biochem. 91 (1): 100–17. doi:10.1002/jcb.10729. PMID 14689584. 
  • Muthumani K, Desai BM, Hwang DS, et al. (2004). "HIV-1 Vpr and anti-inflammatory activity.". DNA Cell Biol. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381. 
  • Schmitz ML, Mattioli I, Buss H, Kracht M (2005). "NF-kappaB: a multifaceted transcription factor regulated at several levels.". Chembiochem 5 (10): 1348–58. doi:10.1002/cbic.200400144. PMID 15457532. 
  • Pise-Masison CA, Brady JN (2006). "Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.". Front. Biosci. 10: 919–30. PMID 15569630. 
  • Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. PMID 15638726. 
  • Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle.". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353. 
  • Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation.". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175. 
  • Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses.". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944. 
  • Muthumani K, Choo AY, Hwang DS, et al. (2006). "HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis.". Current drug delivery 1 (4): 335–44. PMID 16305395. 
  • Courtois G, Smahi A (2006). "NF-kappaB-related genetic diseases.". Cell Death Differ. 13 (5): 843–51. doi:10.1038/sj.cdd.4401841. PMID 16397577. 
  • Mattson MP, Meffert MK (2006). "Roles for NF-kappaB in nerve cell survival, plasticity, and disease.". Cell Death Differ. 13 (5): 852–60. doi:10.1038/sj.cdd.4401837. PMID 16397579. 
  • Schmitz ML, Krappmann D (2006). "Controlling NF-kappaB activation in T cells by costimulatory receptors.". Cell Death Differ. 13 (5): 834–42. doi:10.1038/sj.cdd.4401845. PMID 16410801. 
  • Janssens S, Tschopp J (2006). "Signals from within: the DNA-damage-induced NF-kappaB response.". Cell Death Differ. 13 (5): 773–84. doi:10.1038/sj.cdd.4401843. PMID 16410802. 
  • Perkins ND, Gilmore TD (2006). "Good cop, bad cop: the different faces of NF-kappaB.". Cell Death Differ. 13 (5): 759–72. doi:10.1038/sj.cdd.4401838. PMID 16410803. 
  • Weil R, Israël A (2006). "Deciphering the pathway from the TCR to NF-kappaB.". Cell Death Differ. 13 (5): 826–33. doi:10.1038/sj.cdd.4401856. PMID 16439988. 
  • Kim HJ, Hawke N, Baldwin AS (2006). "NF-kappaB and IKK as therapeutic targets in cancer.". Cell Death Differ. 13 (5): 738–47. doi:10.1038/sj.cdd.4401877. PMID 16485028. 
  • Braun T, Carvalho G, Fabre C, et al. (2006). "Targeting NF-kappaB in hematologic malignancies.". Cell Death Differ. 13 (5): 748–58. doi:10.1038/sj.cdd.4401874. PMID 16498458. 
  • Bottero V, Withoff S, Verma IM (2006). "NF-kappaB and the regulation of hematopoiesis.". Cell Death Differ. 13 (5): 785–97. doi:10.1038/sj.cdd.4401888. PMID 16528384. 
  • Xiao G (2007). "Autophagy and NF-kappaB: fight for fate.". Cytokine Growth Factor Rev. 18 (3-4): 233–43. doi:10.1016/j.cytogfr.2007.04.006. PMID 17485237. 

[edit] External links

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD
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