NFIL3

From Wikipedia, the free encyclopedia

Nuclear factor, interleukin 3 regulated

Identifiers

NFIL3; E4BP4; IL3BP1; NF-IL3A; NFIL3A

External IDs

OMIM: 605327 MGI: 109495 HomoloGene: 3928

Gene ontology
Molecular Function:	• transcription factor activity • transcription corepressor activity • sequence-specific DNA binding • protein dimerization activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005384 (mRNA)
NP_005375 (protein)

XM_001000125 (mRNA)
XP_001000125 (protein)

Location

Chr 9: 93.21 - 93.23 Mb

Chr 13: 52.98 - 52.99 Mb

Pubmed search

[1]

[2]

Nuclear factor, interleukin 3 regulated, also known as NFIL3, is a human gene.^[1]

[edit] References

^ Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated.

[edit] Further reading

Cowell IG, Skinner A, Hurst HC (1992). "Transcriptional repression by a novel member of the bZIP family of transcription factors.". Mol. Cell. Biol. 12 (7): 3070–7. PMID 1620116.
Zhang W, Zhang J, Kornuc M, et al. (1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter.". Mol. Cell. Biol. 15 (11): 6055–63. PMID 7565758.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. PMID 8076819.
Cowell IG, Hurst HC (1996). "Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1.". Nucleic Acids Res. 24 (18): 3607–13. PMID 8836190.
Ikushima S, Inukai T, Inaba T, et al. (1997). "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2609–14. PMID 9122243.
Hulme DJ, Blair IP, Dawkins JL, Nicholson GA (2000). "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis.". Hum. Genet. 106 (6): 594–6. PMID 10942106.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ozkurt IC, Tetradis S (2003). "Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts.". J. Biol. Chem. 278 (29): 26803–9. doi:10.1074/jbc.M212652200. PMID 12743120.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Priceman SJ, Kirzner JD, Nary LJ, et al. (2006). "Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells.". Biochem. Biophys. Res. Commun. 344 (2): 491–9. doi:10.1016/j.bbrc.2006.03.169. PMID 16630563.