NFATC2

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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
PDB rendering based on 1a02.
Available structures: 1a02, 1owr, 1p7h, 1pzu, 1s9k, 2as5
Identifiers
Symbol(s) NFATC2; KIAA0611; NFAT1; NFATP
External IDs OMIM: 600490 MGI102463 HomoloGene7861
Orthologs
Human Mouse
Entrez 4773 18019
Ensembl ENSG00000101096 ENSMUSG00000027544
Uniprot Q13469 Q6P3F6
Refseq NM_012340 (mRNA)
NP_036472 (protein)
NM_001037177 (mRNA)
NP_001032254 (protein)
Location Chr 20: 49.44 - 49.59 Mb Chr 2: 168.17 - 168.29 Mb
Pubmed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2, also known as NFATC2, is a human gene.

This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]

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[edit] References

[edit] Further reading

  • Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function.". Annu. Rev. Immunol. 15: 707-47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705. 
  • Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.". Cell 96 (5): 611-4. PMID 10089876. 
  • Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation.". J. Cell Biol. 156 (5): 771-4. doi:10.1083/jcb.200111073. PMID 11877454. 
  • Aramburu J, Azzoni L, Rao A, Perussia B (1995). "Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding.". J. Exp. Med. 182 (3): 801-10. PMID 7650486. 
  • Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263-72. PMID 7757816. 
  • Li X, Ho SN, Luna J, et al. (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp.". Cytogenet. Cell Genet. 68 (3-4): 185-91. PMID 7842733. 
  • Ho S, Timmerman L, Northrop J, Crabtree GR (1995). "Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.". Adv. Exp. Med. Biol. 365: 167-73. PMID 7887301. 
  • Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.". Eur. J. Immunol. 24 (11): 2646-52. PMID 7957556. 
  • Vacca A, Farina M, Maroder M, et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif.". Biochem. Biophys. Res. Commun. 205 (1): 467-74. doi:10.1006/bbrc.1994.2689. PMID 7999066. 
  • Northrop JP, Ho SN, Chen L, et al. (1994). "NF-AT components define a family of transcription factors targeted in T-cell activation.". Nature 369 (6480): 497-502. doi:10.1038/369497a0. PMID 8202141. 
  • Jain J, McCaffrey PG, Miner Z, et al. (1993). "The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun.". Nature 365 (6444): 352-5. doi:10.1038/365352a0. PMID 8397339. 
  • Luo C, Burgeon E, Carew JA, et al. (1996). "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes.". Mol. Cell. Biol. 16 (7): 3955-66. PMID 8668213. 
  • Di Somma MM, Majolini MB, Burastero SE, et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering.". Eur. J. Immunol. 26 (9): 2181-8. PMID 8814265. 
  • Copeland KF, McKay PJ, Rosenthal KL (1996). "Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element.". AIDS Res. Hum. Retroviruses 12 (2): 143-8. PMID 8834464. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Hodge MR, Chun HJ, Rengarajan J, et al. (1997). "NF-AT-Driven interleukin-4 transcription potentiated by NIP45.". Science 274 (5294): 1903-5. PMID 8943202. 
  • Lyakh L, Ghosh P, Rice NR (1997). "Expression of NFAT-family proteins in normal human T cells.". Mol. Cell. Biol. 17 (5): 2475-84. PMID 9111316. 
  • Amasaki Y, Masuda ES, Imamura R, et al. (1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets.". J. Immunol. 160 (5): 2324-33. PMID 9498773. 
  • Chen L, Glover JN, Hogan PG, et al. (1998). "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.". Nature 392 (6671): 42-8. doi:10.1038/32100. PMID 9510247. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.