NFAT5

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Nuclear factor of activated T-cells 5, tonicity-responsive
PDB rendering based on 1imh.
Available structures: 1imh
Identifiers
Symbol(s) NFAT5; KIAA0827; NF-AT5; NFATL1; NFATZ; OREBP; TONEBP
External IDs OMIM: 604708 MGI: 1859333 HomoloGene: 4811
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10725 54446
Ensembl ENSG00000102908 ENSMUSG00000003847
Uniprot O94916 Q3UW17
Refseq NM_006599 (mRNA)
NP_006590 (protein)		 NM_018823 (mRNA)
NP_061293 (protein)
Location Chr 16: 68.16 - 68.3 Mb Chr 8: 110.18 - 110.27 Mb
Pubmed search [1] [2]

Nuclear factor of activated T-cells 5, tonicity-responsive, also known as NFAT5, is a human gene.[1]

The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive.

[edit] Further reading

  • López-Rodríguez C, Aramburu J, Rakeman AS, et al. (2001). "NF-AT5: the NF-AT family of transcription factors expands in a new direction.". Cold Spring Harb. Symp. Quant. Biol. 64: 517-26. PMID 11233530. 
  • Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation.". J. Cell Biol. 156 (5): 771-4. doi:10.1083/jcb.200111073. PMID 11877454. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355-64. PMID 10048485. 
  • Miyakawa H, Woo SK, Dahl SC, et al. (1999). "Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2538-42. PMID 10051678. 
  • Lopez-Rodríguez C, Aramburu J, Rakeman AS, Rao A (1999). "NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7214-9. PMID 10377394. 
  • Zühlke C, Kiehl R, Johannsmeyer A, et al. (2000). "Isolation and characterization of novel CAG repeat containing genes expressed in human brain.". DNA Seq. 10 (1): 1-6. PMID 10565538. 
  • Ko BC, Turck CW, Lee KW, et al. (2000). "Purification, identification, and characterization of an osmotic response element binding protein.". Biochem. Biophys. Res. Commun. 270 (1): 52-61. doi:10.1006/bbrc.2000.2376. PMID 10733904. 
  • Trama J, Lu Q, Hawley RG, Ho SN (2000). "The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner.". J. Immunol. 165 (9): 4884-94. PMID 11046013. 
  • Hebinck A, Dalski A, Engel H, et al. (2000). "Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains.". Cytogenet. Cell Genet. 90 (1-2): 68-70. PMID 11060450. 
  • López-Rodríguez C, Aramburu J, Jin L, et al. (2001). "Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress.". Immunity 15 (1): 47-58. PMID 11485737. 
  • Dalski A, Schwinger E, Zühlke C (2001). "Genomic organization of the human NFAT5 gene: exon-intron structure of the 14-kb transcript and CpG-island analysis of the promoter region.". Cytogenet. Cell Genet. 93 (3-4): 239-41. PMID 11528118. 
  • Stroud JC, Lopez-Rodriguez C, Rao A, Chen L (2002). "Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor.". Nat. Struct. Biol. 9 (2): 90-4. doi:10.1038/nsb749. PMID 11780147. 
  • Ferraris JD, Williams CK, Persaud P, et al. (2002). "Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration.". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 739-44. doi:10.1073/pnas.241637298. PMID 11792870. 
  • Merante F, Altamentova SM, Mickle DA, et al. (2002). "The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to oxygen tension.". Mol. Cell. Biochem. 229 (1-2): 73-83. PMID 11936849. 
  • Jauliac S, López-Rodriguez C, Shaw LM, et al. (2002). "The role of NFAT transcription factors in integrin-mediated carcinoma invasion.". Nat. Cell Biol. 4 (7): 540-4. doi:10.1038/ncb816. PMID 12080349. 
  • Ko BC, Lam AK, Kapus A, et al. (2003). "Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP).". J. Biol. Chem. 277 (48): 46085-92. doi:10.1074/jbc.M208138200. PMID 12359721. 
  • Kneitz C, Goller M, Tony H, et al. (2002). "The CD23b promoter is a target for NF-AT transcription factors in B-CLL cells.". Biochim. Biophys. Acta 1588 (1): 41-7. PMID 12379312. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765. 

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD
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