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New Hampshire Route 121 (abbreviated NH 121) is a 22.53 mile long north-south state highway in Rockingham County in southeastern New Hampshire. The southern terminus of NH 121 is at the Massachusetts state line in Plaistow, where the road, named Atkinson Depot Road, continues into the town of Haverhill as an unnumbered local road. The northern terminus is at a traffic circle, where NH 121 meets New Hampshire Route 28 Bypass (the Londonderry Turnpike) in eastern Manchester. At this point, the road is known as Manchester Road.
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