Neurophysin I

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It has been suggested that this article or section be merged with Oxytocin. (Discuss)

oxytocin, prepro- (neurophysin I)
Identifiers
Symbol	OXT
Alt. Symbols	OT
Entrez	5020
HUGO	8528
OMIM	167050
RefSeq	NM_000915
UniProt	P01178
Other data
Locus	Chr. 20 p13

Neurophysin I is a carrier protein with a size of 10 KDa and containing 90 to 97 aminoacids that transports neurohypophysial hormones along axons, from the hypothalamus to the posterior lobe of the pituitary. This protein is necessary to prevent diffusion of peptide hormones out of the axons. Hormones of the posterior lobe of the pituitary are synthesized in hypothalamic nuclei and are packaged in secretory granules with their respective neurophysins.

Neurophysin I binds oxytocin for transport through the long axon originating in the paraventricular nucleus in the hypothalamus going to the neurohypophysis of the pituitary.

v • d • e Proteins: carrier proteins Hormone Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin Metal/element calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor) Vitamin Retinol binding protein (4) - Transcobalamin Other Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein