Neuropeptide Y receptor Y2

From Wikipedia, the free encyclopedia

Identifiers

External IDs

OMIM: 162642 MGI: 108418 HomoloGene: 701

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • peptide YY receptor activity • receptor activity • calcium channel regulator activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase inhibiting pathway • circadian rhythm • locomotory behavior • feeding behavior

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000910 (mRNA)
NP_000901 (protein)

NM_008731 (mRNA)
NP_032757 (protein)

Location

Chr 4: 156.35 - 156.36 Mb

Chr 3: 82.62 - 82.63 Mb

Pubmed search

[1]

[2]

Neuropeptide Y receptor Y2, also known as NPY2R, is a human gene.^[1]

[edit] See also

Neuropeptide Y receptor

[edit] References

^ Entrez Gene: NPY2R neuropeptide Y receptor Y2.

[edit] Further reading

Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055–64. PMID 9001438.
Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. PMID 12007534.
Herzog H, Hort YJ, Ball HJ, et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems.". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. PMID 1321422.
Rose PM, Fernandes P, Lynch JS, et al. (1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.". J. Biol. Chem. 270 (39): 22661–4. PMID 7559383.
Gerald C, Walker MW, Vaysse PJ, et al. (1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.". J. Biol. Chem. 270 (45): 26758–61. PMID 7592910.
Lynch JW, Lemos VS, Bucher B, et al. (1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line.". J. Biol. Chem. 269 (11): 8226–33. PMID 8132547.
Gehlert DR, Beavers LS, Johnson D, et al. (1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor.". Mol. Pharmacol. 49 (2): 224–8. PMID 8632753.
Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661–5. PMID 8643460.
Ammar DA, Eadie DM, Wong DJ, et al. (1997). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.". Genomics 38 (3): 392–8. PMID 8975716.
Snow BE, Hall RA, Krumins AM, et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.". J. Biol. Chem. 273 (28): 17749–55. PMID 9651375.
Caberlotto L, Fuxe K, Rimland JM, et al. (1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain.". Neuroscience 86 (1): 167–78. PMID 9692752.
Goumain M, Voisin T, Lorinet AM, et al. (2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.". Mol. Pharmacol. 60 (1): 124–34. PMID 11408607.
Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMID 11906964.
Uddman R, Möller S, Nilsson T, et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.". Peptides 23 (5): 927–34. PMID 12084524.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hyland NP, Sjöberg F, Tough IR, et al. (2004). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues.". Br. J. Pharmacol. 139 (4): 863–71. doi:10.1038/sj.bjp.0705298. PMID 12813010.
Hung CC, Pirie F, Luan J, et al. (2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.". Diabetes 53 (9): 2461–6. PMID 15331560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened