Neuropeptide Y receptor Y1

From Wikipedia, the free encyclopedia

Identifiers

External IDs

OMIM: 162641 MGI: 104963 HomoloGene: 700

Gene ontology
Molecular Function:	• rhodopsin-like receptor activity • peptide YY receptor activity • pancreatic polypeptide receptor activity • receptor activity • neuropeptide Y receptor activity • protein binding
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• glucose metabolic process • signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • G-protein signaling, adenylate cyclase inhibiting pathway • neuropeptide signaling pathway • locomotory behavior • feeding behavior • blood pressure regulation • sensory perception of pain • regulation of body size

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000909 (mRNA)
NP_000900 (protein)

NM_010934 (mRNA)
NP_035064 (protein)

Location

Chr 4: 164.46 - 164.47 Mb

Chr 8: 69.63 - 69.64 Mb

Pubmed search

[1]

[2]

Neuropeptide Y receptor Y1, also known as NPY1R, is a human gene.^[1]

[edit] See also

Neuropeptide Y receptor

[edit] References

^ Entrez Gene: NPY1R neuropeptide Y receptor Y1.

[edit] Further reading

Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055–64. PMID 9001438.
Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173–87. PMID 12007534.
Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y.". Biopolymers 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475.
Larhammar D, Blomqvist AG, Yee F, et al. (1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.". J. Biol. Chem. 267 (16): 10935–8. PMID 1317848.
Herzog H, Hort YJ, Ball HJ, et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems.". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. PMID 1321422.
Rose PM, Fernandes P, Lynch JS, et al. (1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.". J. Biol. Chem. 270 (39): 22661–4. PMID 7559383.
Herzog H, Baumgartner M, Vivero C, et al. (1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.". J. Biol. Chem. 268 (9): 6703–7. PMID 8095935.
Gicquiaux H, Lecat S, Gaire M, et al. (2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor.". J. Biol. Chem. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903.
Sheriff S, F Qureshy A, T Chance W, et al. (2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected].". Peptides 23 (1): 87–96. PMID 11814622.
Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMID 11906964.
Uddman R, Möller S, Nilsson T, et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.". Peptides 23 (5): 927–34. PMID 12084524.
Cantó Soler MV, Gallo JE, Dodds RA, et al. (2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina.". Glia 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Berglund MM, Schober DA, Statnick MA, et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction.". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Körner M, Waser B, Reubi JC (2005). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia.". Clin. Cancer Res. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622.

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v • d • e Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)

Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))

Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened