Neuropeptide Y receptor

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Identifiers
Symbol NPY1R
Alt. Symbols NPYR
Entrez 4886
HUGO 7956
OMIM 162641
RefSeq NM_000909
UniProt P25929
Other data
Locus Chr. 4 q31.3-q32
Identifiers
Symbol NPY2R
Entrez 4887
HUGO 7957
OMIM 162642
RefSeq NM_000910
UniProt P49146
Other data
Locus Chr. 4 q31
Identifiers
Symbol PPYR1
Alt. Symbols NPY4R, Y4, PP1
Entrez 5540
HUGO 9329
OMIM 601790
RefSeq NM_005972
UniProt P50391
Other data
Locus Chr. 10 q11.2
Identifiers
Symbol NPY5R
Entrez 4889
HUGO 7958
OMIM 602001
RefSeq NM_006174
UniProt Q15761
Other data
Locus Chr. 4 q31-q32

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.[1] These receptors are involved in control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.

[edit] Types

There are five known mammalian neuropeptide y receptors designated Y1 through Y5.[2] Four neuropeptide y receptors each encoded by a different gene have been identified in humans:

[edit] References

  1. ^ Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (March 1998). "XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors". Pharmacol. Rev. 50 (1): 143–50. PMID 9549761. 
  2. ^ Larhammar D, Salaneck E (2004). "Molecular evolution of NPY receptor subtypes". Neuropeptides 38 (4): 141–51. doi:10.1016/j.npep.2004.06.002. PMID 15337367. 

[edit] External links