NEU4

From Wikipedia, the free encyclopedia

Sialidase 4

Identifiers

NEU4; MGC102757; MGC18222

External IDs

OMIM: 608527 MGI: 2661364 HomoloGene: 15433

Gene ontology
Molecular Function:	• exo-alpha-sialidase activity • hydrolase activity, acting on glycosyl bonds
Cellular Component:	• lysosome • membrane • organelle inner membrane
Biological Process:	• metabolic process

Orthologs

Human

Mouse

Refseq

NM_080741 (mRNA)
NP_542779 (protein)

NM_173772 (mRNA)
NP_776133 (protein)

Location

Chr 2: 242.4 - 242.41 Mb

Chr 1: 95.85 - 95.86 Mb

Pubmed search

[1]

[2]

Sialidase 4, also known as NEU4, is a human gene.^[1]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.^[1]

[edit] References

^ ^a ^b Entrez Gene: NEU4 sialidase 4.

[edit] Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase.". Gene 321: 155–61. PMID 14637003.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Monti E, Bassi MT, Bresciani R, et al. (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family.". Genomics 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670.
Seyrantepe V, Landry K, Trudel S, et al. (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells.". J. Biol. Chem. 279 (35): 37021–9. doi:10.1074/jbc.M404531200. PMID 15213228.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Stamatos NM, Liang F, Nan X, et al. (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.