NEU3

From Wikipedia, the free encyclopedia

Sialidase 3 (membrane sialidase)

Identifiers

NEU3; FLJ12388; SIAL3

External IDs

OMIM: 604617 MGI: 1355305 HomoloGene: 4847

Gene ontology
Molecular Function:	• exo-alpha-sialidase activity • hydrolase activity, acting on glycosyl bonds
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• carbohydrate metabolic process • ganglioside catabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006656 (mRNA)
NP_006647 (protein)

NM_016720 (mRNA)
NP_057929 (protein)

Location

Chr 11: 74.38 - 74.4 Mb

Chr 7: 99.69 - 99.7 Mb

Pubmed search

[1]

[2]

Sialidase 3 (membrane sialidase), also known as NEU3, is a human gene.^[1]

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.^[1]

[edit] References

^ ^a ^b Entrez Gene: NEU3 sialidase 3 (membrane sialidase).

[edit] Further reading

Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.". J. Virol. 70 (11): 7462-70. PMID 8892864.
Wada T, Yoshikawa Y, Tokuyama S, et al. (1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase.". Biochem. Biophys. Res. Commun. 261 (1): 21-7. doi:10.1006/bbrc.1999.0973. PMID 10405317.
Monti E, Bassi MT, Papini N, et al. (2001). "Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane.". Biochem. J. 349 (Pt 1): 343-51. PMID 10861246.
Wang Y, Yamaguchi K, Wada T, et al. (2002). "A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains.". J. Biol. Chem. 277 (29): 26252-9. doi:10.1074/jbc.M110515200. PMID 12011038.
Kakugawa Y, Wada T, Yamaguchi K, et al. (2002). "Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression.". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10718-23. doi:10.1073/pnas.152597199. PMID 12149448.
Hart ML, Saifuddin M, Uemura K, et al. (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1.". AIDS Res. Hum. Retroviruses 18 (17): 1311-7. doi:10.1089/088922202320886352. PMID 12487819.
Oehler C, Kopitz J, Cantz M (2003). "Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue.". Biol. Chem. 383 (11): 1735-42. PMID 12530538.
Sasaki A, Hata K, Suzuki S, et al. (2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice.". J. Biol. Chem. 278 (30): 27896-902. doi:10.1074/jbc.M212200200. PMID 12730204.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Ha KT, Lee YC, Cho SH, et al. (2004). "Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli.". Mol. Cells 17 (2): 267-73. PMID 15179041.
Stamatos NM, Liang F, Nan X, et al. (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.". FEBS J. 272 (10): 2545-56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.
Kato K, Shiga K, Yamaguchi K, et al. (2006). "Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling.". Biochem. J. 394 (Pt 3): 647-56. doi:10.1042/BJ20050737. PMID 16241905.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Ueno S, Saito S, Wada T, et al. (2006). "Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility.". J. Biol. Chem. 281 (12): 7756-64. doi:10.1074/jbc.M509668200. PMID 16428383.
Yamaguchi K, Hata K, Wada T, et al. (2006). "Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles.". Biochem. Biophys. Res. Commun. 346 (2): 484-90. doi:10.1016/j.bbrc.2006.05.136. PMID 16765317.
Nan X, Carubelli I, Stamatos NM (2007). "Sialidase expression in activated human T lymphocytes influences production of IFN-gamma.". J. Leukoc. Biol. 81 (1): 284-96. doi:10.1189/jlb.1105692. PMID 17028199.
Yoshizumi S, Suzuki S, Hirai M, et al. (2007). "Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice.". Metab. Clin. Exp. 56 (3): 420-9. doi:10.1016/j.metabol.2006.10.027. PMID 17292733.
Wada T, Hata K, Yamaguchi K, et al. (2007). "A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells.". Oncogene 26 (17): 2483-90. doi:10.1038/sj.onc.1210341. PMID 17334392.
Azuma Y, Sato H, Higai K, Matsumoto K (2007). "Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis.". Biol. Pharm. Bull. 30 (9): 1680-4. PMID 17827720.