NET1

From Wikipedia, the free encyclopedia

Neuroepithelial cell transforming gene 1

Identifiers

NET1; ARHGEF8; NET1A

External IDs

OMIM: 606450 MGI: 1927138 HomoloGene: 4283

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity
Cellular Component:	• cellular_component • intracellular • nucleus
Biological Process:	• regulation of cell growth • signal transduction • regulation of Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001047160 (mRNA)
NP_001040625 (protein)

NM_001047159 (mRNA)
NP_001040624 (protein)

Location

Chr 10: 5.44 - 5.49 Mb

Chr 13: 3.88 - 3.92 Mb

Pubmed search

[1]

[2]

Neuroepithelial cell transforming gene 1, also known as NET1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NET1 neuroepithelial cell transforming gene 1.

[edit] Further reading

Chan AM, Takai S, Yamada K, Miki T (1996). "Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning.". Oncogene 12 (6): 1259–66. PMID 8649828.
Shen X, Li J, Hu PP, et al. (2001). "The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.". J. Biol. Chem. 276 (18): 15362–8. doi:10.1074/jbc.M009534200. PMID 11278519.
Dobrosotskaya IY (2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1.". Biochem. Biophys. Res. Commun. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID 11350080.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Qin H, Carr HS, Wu X, et al. (2005). "Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1.". J. Biol. Chem. 280 (9): 7603–13. doi:10.1074/jbc.M412141200. PMID 15611121.
Alberts AS, Qin H, Carr HS, Frost JA (2005). "PAK1 negatively regulates the activity of the Rho exchange factor NET1.". J. Biol. Chem. 280 (13): 12152–61. doi:10.1074/jbc.M405073200. PMID 15684429.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Leyden J, Murray D, Moss A, et al. (2006). "Net1 and Myeov: computationally identified mediators of gastric cancer.". Br. J. Cancer 94 (8): 1204–12. doi:10.1038/sj.bjc.6603054. PMID 16552434.
García-Mata R, Dubash AD, Sharek L, et al. (2007). "The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.". Mol. Cell. Biol. 27 (24): 8683–97. doi:10.1128/MCB.00157-07. PMID 17938206.