NEK3

From Wikipedia, the free encyclopedia

NIMA (never in mitosis gene a)-related kinase 3

Identifiers

NEK3; HSPK36; MGC29949

External IDs

OMIM: 604044 MGI: 1344371 HomoloGene: 1869

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• protein amino acid phosphorylation • cell cycle • mitosis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002498 (mRNA)
NP_002489 (protein)

NM_011848 (mRNA)
NP_035978 (protein)

Location

Chr 13: 51.6 - 51.63 Mb

Chr 8: 23.59 - 23.63 Mb

Pubmed search

[1]

[2]

NIMA (never in mitosis gene a)-related kinase 3, also known as NEK3, is a human gene.^[1]

In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. Three transcript variants have been found for this gene, but the full-length nature of only two of them has been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: NEK3 NIMA (never in mitosis gene a)-related kinase 3.

[edit] Further reading

Schultz SJ, Fry AM, Sütterlin C, et al. (1994). "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.". Cell Growth Differ. 5 (6): 625-35. PMID 7522034.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821-30. PMID 8274451.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Tanaka K, Nigg EA (1999). "Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators.". J. Biol. Chem. 274 (19): 13491-7. PMID 10224116.
Kimura M, Okano Y (2002). "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3).". Cytogenet. Cell Genet. 95 (3-4): 177-82. PMID 12063396.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Miller SL, DeMaria JE, Freier DO, et al. (2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.". Mol. Endocrinol. 19 (4): 939-49. doi:10.1210/me.2004-0443. PMID 15618286.
Hernández M, Almeida TA (2007). "Is there any association between nek3 and cancers with frequent 13q14 deletion?". Cancer Invest. 24 (7): 682-8. doi:10.1080/07357900600981364. PMID 17118778.
Miller SL, Antico G, Raghunath PN, et al. (2007). "Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.". Oncogene 26 (32): 4668-78. doi:10.1038/sj.onc.1210264. PMID 17297458.