NEK1

From Wikipedia, the free encyclopedia

NIMA (never in mitosis gene a)-related kinase 1

Identifiers

NEK1; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800; NY-REN-55

External IDs

OMIM: 604588 MGI: 97303 HomoloGene: 14376

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Cellular Component:	• cellular_component • nucleus • cytoplasm
Biological Process:	• protein amino acid phosphorylation • cell cycle • mitosis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012224 (mRNA)
NP_036356 (protein)

XM_620663 (mRNA)
XP_620663 (protein)

Location

Chr 4: 170.55 - 170.77 Mb

Chr 8: 63.89 - 64.02 Mb

Pubmed search

[1]

[2]

NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene.^[1]

[edit] References

^ Entrez Gene: NEK1 NIMA (never in mitosis gene a)-related kinase 1.

[edit] Further reading

Letwin K, Mizzen L, Motro B, et al. (1992). "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.". EMBO J. 11 (10): 3521–31. PMID 1382974.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. PMID 10508479.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.". DNA Res. 8 (4): 179–87. PMID 11572484.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Polci R, Peng A, Chen PL, et al. (2005). "NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.". Cancer Res. 64 (24): 8800–3. doi:10.1158/0008-5472.CAN-04-2243. PMID 15604234.