NEIL2

From Wikipedia, the free encyclopedia

Nei like 2 (E. coli)

Identifiers

NEIL2; FLJ31644; MGC2832; MGC4505; NEH2

External IDs

OMIM: 608933 MGI: 2686058 HomoloGene: 17032

Gene ontology
Molecular Function:	• damaged DNA binding • microtubule binding • zinc ion binding • oxidized purine base lesion DNA N-glycosylase activity • hydrolase activity, acting on glycosyl bonds • lyase activity • metal ion binding
Cellular Component:	• nucleus • cytoplasm • spindle microtubule
Biological Process:	• base-excision repair • metabolic process

Orthologs

Human

Mouse

Refseq

NM_145043 (mRNA)
NP_659480 (protein)

NM_201610 (mRNA)
NP_963904 (protein)

Location

Chr 8: 11.66 - 11.68 Mb

Chr 14: 62.14 - 62.15 Mb

Pubmed search

[1]

[2]

Nei like 2 (E. coli), also known as NEIL2, is a human gene.^[1]

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002)[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: NEIL2 nei like 2 (E. coli).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Hazra TK, Kow YW, Hatahet Z, et al. (2002). "Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.". J. Biol. Chem. 277 (34): 30417–20. doi:10.1074/jbc.C200355200. PMID 12097317.
Takao M, Kanno S, Kobayashi K, et al. (2003). "A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue.". J. Biol. Chem. 277 (44): 42205–13. doi:10.1074/jbc.M206884200. PMID 12200441.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bandaru V, Sunkara S, Wallace SS, Bond JP (2003). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII.". DNA Repair (Amst.) 1 (7): 517–29. PMID 12509226.
Dou H, Mitra S, Hazra TK (2004). "Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2.". J. Biol. Chem. 278 (50): 49679–84. doi:10.1074/jbc.M308658200. PMID 14522990.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Katafuchi A, Nakano T, Masaoka A, et al. (2004). "Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions.". J. Biol. Chem. 279 (14): 14464–71. doi:10.1074/jbc.M400393200. PMID 14734554.
Bhakat KK, Hazra TK, Mitra S (2004). "Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity.". Nucleic Acids Res. 32 (10): 3033–9. doi:10.1093/nar/gkh632. PMID 15175427.
Das A, Rajagopalan L, Mathura VS, et al. (2004). "Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein.". J. Biol. Chem. 279 (45): 47132–8. doi:10.1074/jbc.M406224200. PMID 15339932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Das A, Wiederhold L, Leppard JB, et al. (2007). "NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells.". DNA Repair (Amst.) 5 (12): 1439–48. doi:10.1016/j.dnarep.2006.07.003. PMID 16982218.
Broderick P, Bagratuni T, Vijayakrishnan J, et al. (2006). "Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.". BMC Cancer 6: 243. doi:10.1186/1471-2407-6-243. PMID 17029639.
Katafuchi A, Matsubara M, Terato H, et al. (2007). "Damage specificity of human DNA glycosylases for oxidative pyrimidine lesions.". Nucleic Acids Symp Ser (Oxf) (48): 175–6. doi:10.1093/nass/48.1.175. PMID 17150535.
Das S, Chattopadhyay R, Bhakat KK, et al. (2007). "Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress.". J. Biol. Chem. 282 (39): 28474–84. doi:10.1074/jbc.M704672200. PMID 17686777.