NEFM

From Wikipedia, the free encyclopedia

Neurofilament, medium polypeptide 150kDa

Identifiers

NEFM; NEF3; NF-M; NFM

External IDs

OMIM: 162250 MGI: 97314 HomoloGene: 38041

Gene ontology
Molecular Function:	• structural constituent of cytoskeleton
Cellular Component:	• neurofilament • axon
Biological Process:	• intermediate filament cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005382 (mRNA)
NP_005373 (protein)

NM_008691 (mRNA)
NP_032717 (protein)

Location

Chr 8: 24.83 - 24.83 Mb

Chr 14: 67.07 - 67.08 Mb

Pubmed search

[1]

[2]

Neurofilament, medium polypeptide 150kDa, also known as NEFM, is a human gene.^[1]

[edit] References

^ Entrez Gene: NEFM neurofilament, medium polypeptide 150kDa.

[edit] Further reading

Ding Y, Reed DR, Baltazar MC, Price RA (1992). "RFLP for BgI II at the human neurofilament medium chain (NEF3) gene locus.". Nucleic Acids Res. 20 (6): 1429. PMID 1348579.
Xu ZS, Liu WS, Willard MB (1992). "Identification of six phosphorylation sites in the COOH-terminal tail region of the rat neurofilament protein M.". J. Biol. Chem. 267 (7): 4467–71. PMID 1537832.
Lee VM, Otvos L, Carden MJ, et al. (1988). "Identification of the major multiphosphorylation site in mammalian neurofilaments.". Proc. Natl. Acad. Sci. U.S.A. 85 (6): 1998–2002. PMID 2450354.
Chin TK, Harding SE, Eagles PA (1990). "Characterization of two proteolytically derived soluble polypeptides from the neurofilament triplet components NFM and NFH.". Biochem. J. 264 (1): 53–60. PMID 2557834.
Myers MW, Lazzarini RA, Lee VM, et al. (1987). "The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.". EMBO J. 6 (6): 1617–26. PMID 3608989.
Tu PH, Elder G, Lazzarini RA, et al. (1995). "Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits.". J. Cell Biol. 129 (6): 1629–40. PMID 7790359.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Dong DL, Xu ZS, Chevrier MR, et al. (1993). "Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M.". J. Biol. Chem. 268 (22): 16679–87. PMID 8344946.
Fleming LM, Weisgraber KH, Strittmatter WJ, et al. (1996). "Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins.". Exp. Neurol. 138 (2): 252–60. doi:10.1006/exnr.1996.0064. PMID 8620924.
Dong DL, Xu ZS, Hart GW, Cleveland DW (1996). "Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H.". J. Biol. Chem. 271 (34): 20845–52. PMID 8702840.
Veeranna , Shetty KT, Takahashi M, et al. (2000). "Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain.". Brain Res. Mol. Brain Res. 76 (2): 229–36. PMID 10762698.
Taylor JP, Sater R, French J, et al. (2002). "Transcription of intermediate filament genes is enhanced in focal cortical dysplasia.". Acta Neuropathol. 102 (2): 141–8. PMID 11563628.
Wang Y, Wang Q, Wang J (2002). "[Detection of level and mutation of neurofilament mRNA in Alzheimer's disease]". Zhonghua Yi Xue Za Zhi 82 (8): 519–22. PMID 12133495.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Bhaskar K, Shareef MM, Sharma VM, et al. (2003). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins.". Neurochem. Int. 44 (1): 35–44. PMID 12963086.
Krüger R, Fischer C, Schulte T, et al. (2004). "Mutation analysis of the neurofilament M gene in Parkinson's disease.". Neurosci. Lett. 351 (2): 125–9. PMID 14583397.
Garcia ML, Lobsiger CS, Shah SB, et al. (2004). "NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth.". J. Cell Biol. 163 (5): 1011–20. doi:10.1083/jcb.200308159. PMID 14662745.
Perez-Olle R, Lopez-Toledano MA, Liem RK (2004). "The G336S variant in the human neurofilament-M gene does not affect its assembly or distribution: importance of the functional analysis of neurofilament variants.". J. Neuropathol. Exp. Neurol. 63 (7): 759–74. PMID 15290901.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex.". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.